Synthesis and antimicrobial studies of Schiff bases of fluoroquinolone

被引：0
|
作者：
Patel, Navin B. [1 ]
Patel, Sarvil D. [1 ]
Patel, Arvind L. [1 ]
Patel, Jaymin C. [1 ]
Patel, Jignesh N. [1 ]
机构：
[1] Veer Narmad S Gujarat Univ, Dept Chem, Surat 395007, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2011年 / 50卷 / 11期
关键词：
Schiff base; fluoroquinolone; antimicrobial; DERIVATIVES; QUINOLONE;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Series of Schiff bases of fluoroquinolone have been synthesized from lead molecule 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-chloro-3-quinolinecarbonyl chloride, converted to hydrazide and further reacted with substituted aldehydes and finally condensed with piperazines. morpholine, imidazole. The title compounds have been characterized by elemental analysis. IR. H-1 NMR spectra. All the synthesized compounds have been screened for their antimicrobial activity against five microbes. Majority of them exhibit moderate activity where as good activity has been observed for S. aureus.
引用
收藏
页码：1645 / 1657
页数：13
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