Proteomics in discovery of hepatocellular carcinoma biomarkers

被引：0
|
作者：
Wu Cheng [1 ]
Li Song-Tao [2 ]
Liu Li-Jie [1 ]
Wang Zhan-Feng
Lu Jun-Hua [3 ]
Liu Bao-Hai [1 ]
Liao Ping [4 ]
Wang Wen-Jing [4 ]
Zhu Liang [1 ]
机构：
[1] Second Mil Med Univ, Dept Gastroenterol, Affiliated Hosp 2, Shanghai 200043, Peoples R China
[2] Second Mil Med Univ, Dept Surg, Eastern Hepatobiliary Surg Hosp, Shanghai 200043, Peoples R China
[3] China Sci & Technol Univ, Dept Stat & Finance, Beijing, Peoples R China
[4] Shanghai Municipal Ctr, Dept Publ Hlth & Mol Biol, Shanghai, Peoples R China
来源：
CHINESE JOURNAL OF CANCER RESEARCH | 2007年 / 19卷 / 03期
关键词：
proteomics; biomarker; hepatocellular carcinoma;
D O I：
10.1007/s11670-007-0159-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective: To discover new proteomic biomarkers of hepatocellular carcinoma. Methods: Surface enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry was used to discover biomarkers for differentiating hepatocellular carcinoma and chronic liver disease. A population of 50 patients with hepatocellular carcinoma and 33 patients with chronic liver disease was studied. Results: Twelve proteomic biomarkers of hepatocellular carcinoma were detected in this study. Three proteomic biomarkers were highly expressed in hepatocellular carcinoma and nine proteomic biomarkers were highly expressed in chronic liver disease. The most valuable proteomic biomarker with m/z=11498 had no similar diagnostic value as alpha-fetoprotein. Conclusion: Some of the twelve proteomic biomarkers may become new biomarkers of hepatocellular carcinoma.
引用
收藏
页码：159 / 164
页数：6
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