Preparation of 90YCl3 radiopharmaceutical precursor for nuclear medicine using technology of centrifugal extractors

被引：8

作者：

Srank, J. ^{[1
,3
]}

Melichar, F. ^{[1
,3
]}

Filyanin, A. T. ^{[2
]}

Tomes, M. ^{[1
,3
]}

Beran, M. ^{[1
,3
]}

机构：

[1] ASCR, Inst Nucl Phys, Publ Res Inst, Radiopharmaceut Dept, Rez 25068, Czech Republic

[2] Russian Acad Sci, Inst Phys Chem & Electrochem, Moscow, Russia

[3] RadioMedic Ltd, Rez 25068, Czech Republic

来源：

APPLIED RADIATION AND ISOTOPES | 2010年 / 68卷 / 12期

关键词：

Y-90 radionuclide precursor; Extraction separation; Centrifugal extractors; Product purity; Analytical control; CARRIER-FREE Y-90; SEPARATION;

D O I：

10.1016/j.apradiso.2010.07.012

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Separation of Y-90 from a parent solution of Sr-90-Y-90 in 05 M nitric acid by two-stage liquid-liquid extraction has been investigated using centrifugal extractors. The extraction agent used was 0.25 M di(2-ethylhexyl)phosphoric acid (D2EHPA) in n-dodecane. Back-extraction used 5 M HCl Evaporation of HCl was performed in a rotary vacuum evaporator. Experience gained during the design, construction and running of more than 100 hot separations is presented A short description of analytical methods used and results of the determination of chemical, radionuclidic and radiochemical purities and sterility are given. (C) 2010 Elsevier Ltd All rights reserved.

引用

页码：2163 / 2168

页数：6

共 5 条

[1] Quality Control of the Radiopharmaceutical Precursor ItraPol (90YCl3) Produced at POLATOM
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[2] Method for 90Sr determination in 90YCl3 solution used as precursor for labeling
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[3] Quality control of no-carrier-added 90YCl3 by estimating the labeling efficiency using its reaction with DOTATOC
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[4] Quality control of no-carrier-added 90YCl3 by estimating the labeling efficiency using its reaction with DOTATOC
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Journal of Radioanalytical and Nuclear Chemistry, 2008, 278 : 25 - 29
[5] Investigation of a Nuclear Medicine Compton Camera for low dose imaging using Timepix3 technology
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