Synthesis and conformational analysis of an α-D-mannopyranosyl(1 → 2)-α-D-mannopyranosyl-(1 → 6)-α-D-mannopyranose mimic

被引：20

作者：

Maria, Silvia

Sanchez-Medina, Inmaculada

Mereghetti, Pierangelo

Belvisi, Laura

Jimenez-Barbero, Jesus

Bernardi, Anna

机构：

[1] CSIC, Ctr Invest Biol, Dept Estructura & Funct Prot, Madrid 28040, Spain

[2] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

[3] CISI, Ctr Eccellenza, I-20133 Milan, Italy

来源：

CARBOHYDRATE RESEARCH | 2007年 / 342卷 / 12-13期

关键词：

carbohydrate mimics; conformational analysis; glycomimetics; mannotrioside;

D O I：

10.1016/j.carres.2007.03.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A mimic of a (1 -> 2),(1 -> 6)-mannotrioside was synthesized by replacing the central mannose unit with an enantiomerically pure. conformationally stable trans-diaxial cyclohexanediol. The three-dimensional structure of the molecule was investigated by NMR spectroscopy supported by molecular modelling and was compared to the known features of the natural mannotrioside. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1859 / 1868

页数：10

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