Progress in Synthesis of Cycloaramides and Self-assembly Behavior

There has been a great interest in the creation of organic nanometer functional materials based on self-assembly of shape-persistent macrocycles via noncovalent interaction due to numerous potential applications in biology, chemistry and material sicence. In this review, we summarize the recent progress in synthesis of cycloaramides assisted by three-center hydrogen bonding and the remote steric effect, and their self-assembly behavior of these macrocycles. The strategies for preparing shape-persistent aromatic oligoamide macrocycies with different cavity sizes were discussed based on the highly efficient, one-step macrocyclization. The self-assembly properties of these cycles can be manipulated by means of altering side chains on the periphery. A brief account of cycloaramides with some applications was given, and their developing trends were also proposed.