The Landscape of Human Cancer Proteins Targeted by SARS-CoV-2

被引：40

作者：

Tutuncuoglu, Bend ^{[1
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Cakir, Merve ^{[1
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Batra, Jyoti ^{[1
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Bouhaddou, Mehdi ^{[1
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Eckhard, Manon ^{[1
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Gordon, David E. ^{[1
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Krogan, Nevan J. ^{[1
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机构：

[1] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA

[2] J David Gladstone Inst, San Francisco, CA USA

[3] Univ Calif San Francisco, Quantitat Biosci Inst, San Francisco, CA 94143 USA

[4] QBI COVID 19 Res Grp QCRG, San Francisco, CA USA

[5] Univ Calif San Francisco, Canc Cell Map Initiat CCMI, San Francisco, CA 94143 USA

[6] Univ Calif San Diego, La Jolla, CA 92093 USA

来源：

CANCER DISCOVERY | 2020年 / 10卷 / 07期

关键词：

DNA-REPLICATION; CELL; PHASE;

D O I：

10.1158/2159-8290.CD-20-0559

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The mapping of SARS-CoV-2 human protein-protein interactions by Gordon and colleagues revealed druggable targets that are hijacked by the virus. Here, we highlight several oncogenic pathways identified at the host-virus interface of SARS-CoV-2 to enable cancer biologists to apply their knowledge for rapid drug repurposing to treat COVID-19, and help inform the response to potential long-term complications of the disease.

引用

页码：916 / 921

页数：6

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