Corticosteroid-use in primary and secondary brain tumour patients: a review

被引：38
|
作者：
Ryan, Richella [1 ]
Booth, Sara [1 ,2 ,3 ]
Price, Stephen [2 ,4 ]
机构：
[1] Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Palliat Care Dept, Cambridge CB2 0QQ, England
[2] Univ Cambridge, Cambridge, England
[3] Kings Coll London, London WC2R 2LS, England
[4] Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Dept Neurosurg, Cambridge CB2 0QQ, England
来源：
JOURNAL OF NEURO-ONCOLOGY | 2012年 / 106卷 / 03期
关键词：
Brain neoplasms; Corticosteroids; Quality of life; GLUCOCORTICOID-RECEPTOR GENE; ENDOTHELIAL GROWTH-FACTOR; CEREBRAL-BLOOD-FLOW; DEXAMETHASONE TREATMENT; CAPILLARY-PERMEABILITY; VASCULAR-PERMEABILITY; INDUCED OSTEOPOROSIS; PHASE-II; EDEMA; EXPRESSION;
D O I：
10.1007/s11060-011-0713-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Corticosteroids have been effective in the management of cerebral oedema, in the context of brain tumours, for many decades. Though their effectiveness is well-established, this needs to be balanced against their potential to cause significant side effects. There is currently little consensus in the literature about how this should be done. This article reviews the literature, specifically in relation to the role of corticosteroids in primary and secondary brain tumour patients. Areas reviewed include corticosteroid pharmacology, indications, mechanism of action, toxicity profile, prescribing practices, and corticosteroid-sparing agents.
引用
收藏
页码：449 / 459
页数：11
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