The molecular pathology of sarcomas

被引：20

作者：

Powers, Martin ^{[2
]}

Zhang, Wei ^{[3
]}

Lopez-Terrada, Dolores ^{[4
]}

Czerniak, Bogdan A. ^{[3
]}

Lazar, Alexander J. ^{[1
,3
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Sarcoma Res Ctr, Houston, TX 77030 USA

[2] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

[4] Texas Childrens Hosp, Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA

来源：

CANCER BIOMARKERS | 2011年 / 9卷 / 1-6期

关键词：

Sarcoma; translocation; EWSR1; reverse transcriptase-polymerase chain reaction (RT-PCR); fluoresence in-situ hybridization (FISH); fusion transcript; molecular diagnostics; pigmented villonodular synovitis; Ewing sarcoma; gastrointestinal stromal tumor (GIST); KIT; PDGRA; karyotype; desmoid fibromatosis; beta-catenin (CTNNB1); malignant peripheral nerve sheath tumor (MPNST); leiomyosarcoma; genomic profiling; GASTROINTESTINAL STROMAL TUMORS; ANEURYSMAL BONE-CYSTS; GIANT-CELL TUMOR; PAROSTEAL OSTEOCHONDROMATOUS PROLIFERATION; COMPARATIVE GENOMIC HYBRIDIZATION; IN-SITU HYBRIDIZATION; PIGMENTED VILLONODULAR SYNOVITIS; MESENCHYMAL PROGENITOR CELLS; FUSION TRANSCRIPT STRUCTURE; SOFT-TISSUE SARCOMAS;

D O I：

10.3233/CBM-2011-0170

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sarcomas are rare malignancies of mesenchymal lineage with more than 100 specific types and many benign potential mimics. In situ and precursor lesions are generally not described and thus much of molecular pathology in this field concentrates on molecular diagnosis, prognosis and determination of therapeutic targets. This chapter discusses the applications of molecular methodologies that provide insight into pathogenesis of sarcoma, and of molecular methods which are currently applied to, or will likely soon influence, the clinical management of this complex array of tumors.

引用

页码：475 / 491

页数：17

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