Controlled cell adhesion on PEG-based switchable surfaces

被引：333
|
作者：
Wischerhoff, Erik [3 ]
Uhlig, Katja [2 ]
Lankenau, Andreas [2 ]
Boerner, Hans G. [4 ]
Laschewsky, Andre [1 ]
Duschl, Claus [2 ]
Lutz, Jean-Francois [3 ]
机构：
[1] Univ Potsdam, D-14476 Potsdam, Germany
[2] Fraunhofer Inst Biomed Engn, D-14476 Potsdam, Germany
[3] Fraunhofer Inst Appl Polymer Res, D-14476 Potsdam, Germany
[4] Max Planck Inst Colloids & Interfaces, D-14476 Potsdam, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 30期
关键词：
biotechnology; cell adhesion; materials science; polymers; surface chemistry;
D O I：
10.1002/anie.200801202
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) A wash and brush up: Thermoresponsive and biocompatible oligo(ethylene glycol)-based copolymers enable the control of cell adhesion on planar gold substrates. While at physiological temperature, the polymer brushes are collapsed and enable fibroblast adhesion and cultivation, at room temperature, the now hydrated oligo(ethylene glycol) segments become cell-repellent, thus allowing cell harvesting under mild conditions (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：5666 / 5668
页数：3
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