Antitussive and immunomodulating activities of instant coffee arabinogalactan-protein

被引：38
|
作者：
Nosal'ova, G. [2 ]
Prisenznakova, L. [2 ]
Paulovicova, E. [1 ]
Capek, P. [1 ]
Matulova, M. [1 ]
Navarini, L. [3 ]
Liverani, F. Suggi [3 ]
机构：
[1] Slovak Acad Sci, Inst Chem, Ctr Glyc, SK-84538 Bratislava, Slovakia
[2] Comenius Univ, Dept Pharmacol, Jessenius Fac Med, Martin 03753, Slovakia
[3] Illycaffe Spa, Res & Innovat, I-34147 Trieste, Italy
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2011年 / 49卷 / 04期
关键词：
Coffea arabica; Instant coffee; Arabinogalactan-protein; Antitussive activity; Immunomodulating activity; TYPE-2; DIABETES-MELLITUS; HUMAN HEALTH; POLYSACCHARIDES; DISEASE; POWDER; CONSUMPTION; INTERFERON; MECHANISMS; CAFFEINE; RISK;
D O I：
10.1016/j.ijbiomac.2011.06.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A low molecular mass arabinogalactan-protein (AGP) composed of galactose and arabinose with a low protein content, isolated from the instant coffee powder of Coffea arabica beans, has been tested on antitussive (in vivo) and immunomodulating (ex vivo) activities. The results of antitussive tests revealed a significant dose dependant cough-suppressive effect of coffee AGP. It was observed 30 or 60 min after AGP administration and its efficacy lasted during the entire experiment course. Immunological tests showed that AGP affected some mediators of immunocompetent cells of immune system as TNF-alpha, IFN-gamma and IL-2 cytokines. It seems that coffee AGP is a good inductor of both pro-inflammatory cytokines TNF-alpha and IFN-gamma, however, less potent in TNF-alpha induction in comparison with that of beta-D-glucan. Evident induction of TNF-alpha, IL-2 and IFN-gamma cytokines, pro-TH1 polarization supports our conclusion about bio-immunological efficacy of AGP with an emphasis on the cellular immunity. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：493 / 497
页数：5
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