Equine arteritis virus is delivered to an acidic compartment of host cells via clathrin-dependent endocytosis

被引：23

作者：

Nitschke, Matthias ^{[2
]}

Korte, Thomas ^{[2
]}

Tielesch, Claudia ^{[1
]}

Ter-Avetisyan, Gohar ^{[3
]}

Tuennemann, Gisela ^{[3
]}

Cardoso, M. Cristina ^{[3
]}

Veit, Michael ^{[1
]}

Herrmann, Andreas ^{[2
]}

机构：

[1] Free Univ Berlin, Fac Vet Med, Dept Immunol & Mol Biol, D-10115 Berlin, Germany

[2] Humboldt Univ, Dept Biol Biophys, D-10115 Berlin, Germany

[3] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany

来源：

VIROLOGY | 2008年 / 377卷 / 02期

关键词：

arteriviridae; EAV; cell entry; clathrin; endocytosis; BHK cells; antisense;

D O I：

10.1016/j.virol.2008.04.041

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Equine arteritis virus (EAV) is an enveloped, positive-stranded RNA virus belonging to the family Arteriviridae. Infection by EAV requires the release of the viral genome by fusion with the respective target membrane of the host cell. We have investigated the entry pathway of EAV into Baby Hamster Kindey cells (BHK). Infection of cells assessed by the plaque reduction assay was strongly inhibited by substances which interfere with clathrin-dependent endocytosis and by lysosomotropic compounds. Furthermore, infection of BHK cells was suppressed when clathrin-dependent endocytosis was inhibited by expression of antisense RNA of the clathrin-heavy chain before infection. These results strongly suggest that EAV is taken up via clathrin-dependent endocytosis and is delivered to acidic endosomal compartments. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：248 / 254

页数：7

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