Pluripotent stem cells in neuropsychiatric disorders

被引：89
|
作者：
Soliman, M. A. [1 ,2 ,3 ]
Aboharb, F. [1 ,4 ]
Zeltner, N. [2 ,3 ]
Studer, L. [1 ,2 ,3 ]
机构：
[1] Cornell Univ, Weill Cornell Med Coll, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Dev Biol, 1275 York Ave,Box 256, New York, NY 10065 USA
[3] Mem Sloan Kettering Canc Ctr, Ctr Stem Cell Biol, New York, NY 10065 USA
[4] Rockefeller Univ, 1230 York Ave, New York, NY 10021 USA
来源：
MOLECULAR PSYCHIATRY | 2017年 / 22卷 / 09期
基金：
美国国家卫生研究院; 瑞士国家科学基金会;
关键词：
DIRECTED DIFFERENTIATION; FUNCTIONAL MATURATION; EPIGENETIC MEMORY; PREFRONTAL CORTEX; DIRECT CONVERSION; HUMAN FIBROBLASTS; GLOBAL BURDEN; ANIMAL-MODEL; RODENT MODEL; NEURONS;
D O I：
10.1038/mp.2017.40
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neuropsychiatric disorders place an enormous medical burden on patients across all social and economic ranks. The current understanding of the molecular and cellular causes of neuropsychiatric disease remains limited, which leads to a lack of targeted therapies. Human-induced pluripotent stem cell (iPSC) technology offers a novel platform for modeling the genetic contribution to mental disorders and yields access to patient-specific cells for drug discovery and personalized medicine. Here, we review recent progress in using iPSC technology to model and potentially treat neuropsychiatric disorders by focusing on the most prevalent conditions in psychiatry, including depression, anxiety disorders, bipolar disorder and schizophrenia.
引用
收藏
页码：1241 / 1249
页数：9
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