Sex- and age-related differences in ceramide dihexosides of primary human brain tumors

被引：0
|
作者：
Yates, AJ
Franklin, TK
Scheithauer, BW
Burger, PC
Pearl, DK
机构：
[1] Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA
[2] Ohio State Univ, Dept Stat, Columbus, OH 43210 USA
[3] Mayo Clin & Mayo Fdn, Dept Pathol, Rochester, MN 55905 USA
[4] Johns Hopkins Univ, Dept Pathol, Baltimore, MD 21287 USA
来源：
LIPIDS | 1999年 / 34卷 / 01期
关键词：
D O I：
10.1007/s11745-999-330-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neutral glycolipids (NGL) are promising diagnostic markers of human gliomas, but differences in NGL with age and sex have not been examined. Previous work demonstrated that ceramide dihexosides (CDH) levels in mouse kidney are age- and sex-dependent, probably due to levels of sex hormones, We quantitated CDH in 181 human gliomas and found significant differences with sex and age, particularly menopause and male puberty. This emphasizes the importance of assessing results of studies on glycolipids in disease stales with respect to age and sex in order to avoid erroneous conclusions concerning the relationship of glycolipid composition with diagnosis and pathogenesis.
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页码：1 / 4
页数：4
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