Bioactive Pimarane-Type Diterpenes from Marine Organisms

被引：24
|
作者：
Wang, Xiaoli [1 ,2 ]
Yu, Haobing [1 ,3 ]
Zhang, Yixin [1 ,3 ]
Lu, Xiaoling [1 ,3 ]
Wang, Bin [4 ]
Liu, Xiaoyu [1 ,3 ]
机构：
[1] Second Mil Med Univ, Marine Biopharmaceut Inst, Xiangyin Rd 800, Shanghai 200433, Peoples R China
[2] Zhejiang Ocean Univ, Marine Sci & Technol Coll, 1 South Haida Rd, Zhoushan 316022, Peoples R China
[3] Second Mil Med Univ, Coll Basic Med Sci, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China
[4] Zhejiang Ocean Univ, Sch Food & Pharm, 1 South Haida Rd, Zhoushan 316022, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2018年 / 15卷 / 01期
基金：
国家高技术研究发展计划(863计划); 中国国家自然科学基金;
关键词：
Marine organisms; Natural products; Secondary metabolites; Pimarane diterpenes; Bioactivity; ISOPIMARANE-TYPE DITERPENOIDS; FUNGUS EUTYPELLA-SCOPARIA; INDIAN MANGROVE PLANTS; CHEMICAL-CONSTITUENTS; A-D; SEA; HS-1;
D O I：
10.1002/cbdv.201700276
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Marine organisms represent an abundant sources of bioactive natural products with unique chemical structure. Pimarane diterpenes are a structurally diverse family of natural products with various biological activities and pharmacological properties. A prolific source of new marine-derived pimarane diterpenes have attracted considerable interest because of their unique structural diversity and varied biological activities, including antimicrobial, antitumor, and antiproliferative activities. This review provides a comprehensive overview of the structures, names, bioactivities, and references of 80 marine-derived pimarane-type natural products for the first time.
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页数：12
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