NoPUMA, no death: Implications for p53-dependent apoptosis

被引：160
|
作者：
Yu, J [1 ]
Zhang, L
机构：
[1] Univ Pittsburgh, Inst Canc, Dept Pathol, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Dept Pharmacol, Pittsburgh, PA 15213 USA
来源：
CANCER CELL | 2003年 / 4卷 / 04期
关键词：
D O I：
10.1016/S1535-6108(03)00249-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
More than a decade ago, it was found that one of the two essential physiological functions of p53 is to selectively destroy stressed cells through apoptosis. Despite the large number of studies describing p53-dependent apoptosis since then, how p53 turns on the apoptotic switch has remained enigmatic. In this issue of Cancer Cell, Jeffers et al. report that knockout of PUMA, a recently identified BH3-only Bcl-2 family protein, recapitulates virtually all apoptotic deficiency in p53 knockout mice. Their results indicate that PUMA is an essential mediator of p53-dependent and -independent apoptosis in vivo.
引用
收藏
页码：248 / 249
页数：2
相关论文
共 50 条
  • [1] p53-dependent apoptosis pathways
    Shen, Y
    White, E
    [J]. ADVANCES IN CANCER RESEARCH, VOL 82, 2001, 82 : 55 - +
  • [2] p53-dependent pathways of apoptosis
    S Benchimol
    [J]. Cell Death & Differentiation, 2001, 8 : 1049 - 1051
  • [3] p53-dependent pathways of apoptosis
    Benchimol, S
    [J]. CELL DEATH AND DIFFERENTIATION, 2001, 8 (11): : 1049 - 1051
  • [4] Pathways of p53-dependent apoptosis
    Grasso, L
    Mercer, WE
    [J]. VITAMINS AND HORMONES - ADVANCES IN RESEARCH AND APPLICATIONS, VOL 53: CELL DEATH PROTEINS, 1997, 53 : 139 - 173
  • [5] Mechanisms of p53-dependent apoptosis
    Schuler, M
    Green, DR
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2001, 29 : 684 - 688
  • [6] Dissecting p53-dependent apoptosis
    Chipuk, J. E.
    Green, D. R.
    [J]. CELL DEATH AND DIFFERENTIATION, 2006, 13 (06): : 994 - 1002
  • [7] Dissecting p53-dependent apoptosis
    J E Chipuk
    D R Green
    [J]. Cell Death & Differentiation, 2006, 13 : 994 - 1002
  • [8] The thousand doors that lead to death - p53-dependent repression and apoptosis
    Murphy, ME
    [J]. CANCER BIOLOGY & THERAPY, 2003, 2 (04) : 381 - 382
  • [9] p53-dependent cell death apoptosis is required for a productive adenovirus infection
    Hall, AR
    Dix, BR
    O'Carroll, SJ
    Braithwaite, AW
    [J]. NATURE MEDICINE, 1998, 4 (09) : 1068 - 1072
  • [10] The function of PML in p53-dependent apoptosis
    Guo, A
    Salomoni, P
    Luo, JY
    Shih, A
    Zhong, S
    Gu, W
    Pandolfi, PP
    [J]. NATURE CELL BIOLOGY, 2000, 2 (10) : 730 - 736
12345