Chromone Derivatives from a Sponge-Derived Strain of the Fungus Corynespora cassiicola

被引:41
|
作者
Zhao, Dong-Lin [1 ]
Shao, Chang-Lun [1 ]
Gan, Li-She [3 ]
Wang, Mei [1 ]
Wang, Chang-Yun [1 ,2 ]
机构
[1] Ocean Univ China, Sch Med & Pharm, Minist Educ China, Key Lab Marine Drugs, Qingdao 266003, Peoples R China
[2] Ocean Univ China, Inst Evolut & Marine Biodivers, Qingdao 266003, Peoples R China
[3] Zhejiang Univ, Coll Pharmaceut Sci, Inst Modern Chinese Med, Hangzhou 310058, Zhejiang, Peoples R China
来源
JOURNAL OF NATURAL PRODUCTS | 2015年 / 78卷 / 02期
基金
中国国家自然科学基金;
关键词
ETHER DERIVATIVES; METABOLITES; SESQUITERPENOIDS; HEPTAKETIDES; GROWTH; ASSAY;
D O I
10.1021/np5009152
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Twelve new chromone derivatives, corynechromones A-L (1-12), were isolated from the sponge-derived fungus Corynespora cassiicola XS-200900I7. Among them, 1/2, 3/4, 5/6, and 7/8 were pairs of epimers. The planar structures were determined by extensive NMR spectroscopic data. The absolute configurations of 1-10 were assigned by the modified Moshers method and TDDFT ECD calculations together with comparison of their CD spectra. These are the first chromone derivatives reported from the genus Corynespora. A possible rule to determine the absolute configurations at C-2 in chromone derivatives by CD was proposed.
引用
收藏
页码:286 / 293
页数:8
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