Effect of sepsis on behavioral changes on the ketamine-induced animal model of schizophrenia

被引：4
|
作者：
Comim, Clarissa M. [1 ]
Silva, Napoleao C. [2 ]
Patricio, Janini J. [1 ]
Palmas, Daphne [1 ]
Mendonca, Bruna P. [2 ]
Bittencourt, Mariana O. [2 ]
Cassol, Omar J., Jr. [1 ]
Barichello, Tatiana [3 ]
Zugno, Alexandra I. [2 ]
Quevedo, Joao [2 ,4 ]
Dal-Pizzol, Felipe [5 ]
机构：
[1] Univ South Santa Catarina, Lab Neuropathol, Postgrad Program Hlth Sci, Palhoca, SC, Brazil
[2] Univ Southern Santa Catarina, Neurosci Lab, Hlth Sci Unit, Postgrad Program Hlth Sci, Criciuma, SC, Brazil
[3] Univ Southern Santa Catarina, Lab Expt Microbiol, Hlth Sci Unit, Postgrad Program Hlth Sci, Criciuma, SC, Brazil
[4] Univ Texas Houston, Sch Med, Ctr Expt Models Psychiat, Dept Psychiat & Behav Sci, Houston, TX USA
[5] Univ Southern Santa Catarina, Lab Expt Physiopathol, Hlth Sci Unit, Postgrad Program Hlth Sci, Criciuma, SC, Brazil
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 281卷
关键词：
Sepsis; Brain; Schizophrenia; Behavior; COGNITIVE IMPAIRMENT; CECAL LIGATION; RAT-BRAIN; SYMPTOMS; INCREASE; RECEPTOR; MEMORY;
D O I：
10.1016/j.jneuroim.2015.02.012
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This study aimed to evaluate the effect of sepsis on behavioral changes on the ketamine-induced animal model of schizophrenia. Male Wistar rats underwent Cecal Ligation and Perporation (CLP) with "basic support" or were sham-operated. After 30 days, the animals were submitted to a model of schizophrenia by injection of Ketamine. The behavior tests were performed after 30 min of the injection of Ketamine or saline. Ketamine in doses of 15 and 25 mg/kg increased locomotor activity, latency to first contact in the social interaction and stereotyped behavior. Some changes caused by sepsis may be associated with a predisposition to develop schizophrenia in the animal model. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：78 / 82
页数：5
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