A novel thermo-responsive system based on β-cyclodextrin-nanocomposite for improving the docetaxel activity

被引：6

作者：

Ghamkhari, Aliyeh ^{[1
,2
]}

Abbasi, Farhang ^{[1
,2
]}

Abbasi, Elmira ^{[1
,2
]}

Ghorbani, Marjan ^{[3
]}

机构：

[1] Sahand Univ Technol, Inst Polymer Mat, Tabriz, Iran

[2] Sahand Univ Technol, Fac Polymer Engn, Tabriz, Iran

[3] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2021年 / 70卷 / 12期

关键词：

Cancer therapy; beta-cyclodextrin; docetaxel; graphene nanocomposites; thermoresponsive; ABC TRIBLOCK COPOLYMER; TRANSFER RADICAL POLYMERIZATION; MECHANICAL-PROPERTIES; RAFT POLYMERIZATION; DELIVERY; GRAPHENE; NANOPARTICLES; DOXORUBICIN;

D O I：

10.1080/00914037.2020.1765357

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Nanomaterials are frequently demonstrating advantages for drug delivery applications due to their high potential in treatment of variety of cancers. This paper reports the development of termoresponsive nanocomposites from graphene/(beta-Cyclodextrin)-star poly(methyl methacrylate)-block-poly(N-Isopropylacrylamide) GO/beta-Cyclodextrin-star-PMMA-b-PNiPAM via reversible addition fragmention chain transfer (RAFT) polymerization. The drug loading efficiency of GO/nanocomposites for DTX was high and 85% efficiency was obtained. The cytotoxicity of the DTX against breast cancer cell line (MCF7) was exhibited by using the cytotoxicity assays (MTT), DAPI staining, and cellular uptake. These intelligent GO/nanocomposites with increased anticancer activity could be chosen as an ideal nanocarrier for anticancer therapy. [GRAPHICS] .

引用

页码：830 / 840

页数：11

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