Catalytic and metal-free intramolecular hydroalkoxylation of alkynes

被引：4
|
作者：
Jean, Alexandre [1 ,2 ]
Rouden, Jacques [1 ]
Maddaluno, Jacques [2 ]
De Paolis, Michael [2 ]
Blanchet, Jerome [1 ]
机构：
[1] Normandie Univ, CNRS, UMR 6507 & FR 3038, ENSICAEN,UNICAEN,Lab LCMT, F-14000 Caen, France
[2] Normandie Univ, CNRS, UMR 6014 & FR 3038, UNIROUEN,INSA Rouen,Lab COBRA, F-76000 Rouen, France
来源：
TETRAHEDRON LETTERS | 2019年 / 60卷 / 07期
关键词：
Hydroalkoxylation; Cyclization; Alkynes; Enol ether; Microwave-assisted synthesis; ENOL ETHERS; CYCLIZATION; ALCOHOLS; SCOPE; ALKYNYLPHENOLS; HYDROAMINATION; DERIVATIVES; MECHANISM; ANALOGS; ROUTE;
D O I：
10.1016/j.tetlet.2019.01.020
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Benzyltrimethylammonium hydroxide act as an efficient metal-free catalyst for the intramolecular hydroalkoxylation of alkynes. Notably, the use of microwave irradiation allowed reaction to operate in only two minutes. Under optimized reaction conditions, linear alkynes bearing aryl and heteroaryl substituents were successfully cyclized with good level of stereoselectivity. (C) 2019 Elsevier Ltd. All rights reserved.
引用
收藏
页码：534 / 537
页数：4
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