The role of molecular imaging in drug discovery and development

被引：92
|
作者：
Hargreaves, R. J. [1 ]
机构：
[1] Merck & Co Inc, Merck Res Labs, West Point, PA USA
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2008年 / 83卷 / 02期
关键词：
D O I：
10.1038/sj.clpt.6100467
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Molecular imaging biomarkers are playing an increasingly important role in efforts to increase the probability of success of drug candidates by helping to validate novel drug targets in support of proof-of-concept testing early in the drug discovery and development process. By facilitating better and faster decision-making, molecule and mechanism-based failures can be identified and eliminated from a research portfolio early in development thereby focusing research efforts on the best drug candidates and therapeutic hypotheses. Molecular imaging can be used to improve the cost-effectiveness of studying unprecedented mechanisms, decrease cycle time, and improve drug pipeline quality.
引用
收藏
页码：349 / 353
页数：5
相关论文
共 50 条
  • [1] The role of functional and molecular imaging in cancer drug discovery and development
    Seddon, BM
    Workman, P
    [J]. BRITISH JOURNAL OF RADIOLOGY, 2003, 76 : S128 - S138
  • [2] Molecular imaging in drug discovery and development
    Rudin, M
    Weissleder, R
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (02) : 123 - 131
  • [3] Molecular imaging in drug discovery and development
    Markus Rudin
    Ralph Weissleder
    [J]. Nature Reviews Drug Discovery, 2003, 2 : 123 - 131
  • [4] Molecular Imaging in Drug Discovery and Development
    Lindner, Jonathan R.
    Link, Jeanne
    [J]. CIRCULATION-CARDIOVASCULAR IMAGING, 2018, 11 (02)
  • [5] Multimodal molecular imaging in drug discovery and development
    Vermeulen, Isabeau
    Isin, Emre M.
    Barton, Patrick
    Cillero-Pastor, Berta
    Heeren, Ron M. A.
    [J]. DRUG DISCOVERY TODAY, 2022, 27 (08) : 2086 - 2099
  • [6] Molecular imaging strategies for drug discovery and development
    Gross, Shimon
    Piwnica-Worms, David
    [J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2006, 10 (04) : 334 - 342
  • [7] Applications of Molecular Imaging in Drug Discovery and Development Process
    Ahn, Byeong-Cheol
    [J]. CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2011, 12 (04) : 459 - 468
  • [8] Molecular imaging : a powerful tool for drug discovery and development
    Saji, Hideo
    [J]. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2008, 128 : 33 - 34
  • [9] Optical molecular imaging in drug discovery and clinical development
    Bednar, Bohumil
    Zhang, Guo-Jun
    Williams, David L., Jr.
    Hargreaves, Richard
    Sur, Cyrille
    [J]. EXPERT OPINION ON DRUG DISCOVERY, 2007, 2 (01) : 65 - 85
  • [10] The Role of Molecular Imaging in Drug Discovery and Development (vol 83, pg 349, 2008)
    Hargreaves, R. J.
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2009, 86 (02) : 221 - 221
12345