Effect of BF3 on the enantioselective reduction of trifluoromethyl ketones using a chiral lactam alcohol with borane

被引：7
|
作者：
Harauchi, Yuki [1 ]
Takakura, Chihiro [1 ]
Furumoto, Toshio [1 ]
Yanagita, Ryo C. [1 ]
Kawanami, Yasuhiro [1 ]
机构：
[1] Kagawa Univ, Fac Agr, Dept Appl Biol, Miki, Kagawa 7610795, Japan
来源：
TETRAHEDRON-ASYMMETRY | 2015年 / 26卷 / 07期
关键词：
GENERATED IN-SITU; OXAZABOROLIDINE-CATALYZED REDUCTION; (TRIFLUOROACETYL)BIPHENYL DERIVATIVES; ASYMMETRIC REDUCTION;
D O I：
10.1016/j.tetasy.2015.02.011
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The addition of BF3 center dot THF to an oxazaborolidine catalyst prepared in situ from chiral lactam alcohol 2 and borane enhanced the enantioselectivities (up to 90% ee) and yield (up to 91%) during the reduction of reactive trifluoromethyl ketones at room temperature. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：333 / 337
页数：5
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