Antagonism of chemokine receptor CCR9 synergises with anti-TNFα immunotherapy to reduce inflammation in the MDR1a-/- mouse model of colitis

被引:0
|
作者
Campbell, J. [1 ]
Ertl, L. [1 ]
Ebsworth, K. [1 ]
McMahon, J. [2 ]
Zhang, P. [2 ]
Chhina, V. [1 ]
Charo, I. [1 ]
Schall, T. [1 ]
机构
[1] ChemoCentryx Inc, Dept Biol, Mountain View, CA USA
[2] ChemoCentryx Inc, Dept Chem, Mountain View, CA USA
来源
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
P037
引用
收藏
页码:S150 / S150
页数:1
相关论文
共 6 条
  • [1] Antagonists of chemokine receptor CCR9 synergize with anti-TNFα immunotherapy to reduce inflammation in the MDR1a-/- mouse model of colitis
    Campbell, James J.
    Ertl, Linda S.
    Ebsworth, Karen J.
    McMahon, Jeffrey P.
    Zhang, Penglie J.
    Chhina, Vicky J.
    Charo, Israel F.
    Schall, Thomas J.
    JOURNAL OF IMMUNOLOGY, 2020, 204 (01):
  • [2] MLN3126, an antagonist of the chemokine receptor CCR9, ameliorates inflammation in a T cell mediated mouse colitis model
    Igaki, Keiko
    Komoike, Yusaku
    Nakamura, Yoshiki
    Watanabe, Takeshi
    Yamasaki, Masashi
    Fleming, Paul
    Yang, Lili
    Soler, Dulce
    Fedyk, Eric
    Tsuchimori, Noboru
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 60 : 160 - 169
  • [3] Dietary bovine immunoglobulins reduce the activity of colitis in the mdr1a-/- mouse model
    Moreto, Miquel
    Miro, Lluisa
    Maijo, Monica
    Polo, Javier
    Crenshaw, Joe
    Campbell, Joy
    Russell, Louis
    Weaver, Eric
    Perez-Bosque, Anna
    FASEB JOURNAL, 2011, 25
  • [4] Small Molecule Inhibition of Chemokine Receptor 'CCR9' Combined With Anti-α4β7 Blocking Antibody Confers Synergistic Protection Against Piroxicam-Accelerated Colitis in Mice
    Tan, Joanne
    Ebsworth, Karen
    Ertl, Linda
    Canivel, Deogracias
    Zhang, Penglie
    Bekker, Pirow
    Schall, Omas
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2014, 109 : S523 - S524
  • [5] γ-Glutamyl cysteine and γ-glutamyl valine inhibit TNF-α signaling in intestinal epithelial cells and reduce inflammation in a mouse model of colitis via allosteric activation of the calcium-sensing receptor
    Zhang, Hua
    Kovacs-Nolan, Jennifer
    Kodera, Tomohiro
    Eto, Yuzuru
    Mine, Yoshinori
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2015, 1852 (05): : 792 - 804
  • [6] Characterization of a mouse model of C5a-induced acute lung injury reveals a role of the C-C chemokine receptor type 5 (CCR5) during C5aR1-dependent inflammation
    Bosmann, Markus
    Russkamp, Norman F.
    Roewe, Julian
    Ward, Peter A.
    MOLECULAR IMMUNOLOGY, 2014, 61 (02) : 243 - 244