Role of estrogen receptors in pro-oxidative and anti-oxidative actions of estrogens: A perspective

被引:65
|
作者
Kumar, Sukhdeep [1 ]
Lata, Kusum [1 ]
Mukhopadhyay, Srirupa [1 ]
Mukherjee, Tapan K. [1 ]
机构
[1] IISER, Dept Biol, Chandigarh 160019, India
来源
关键词
Estrogens; Estrogen receptors; Estrogen receptor related receptors; Pro-oxidative action; Anti-oxidative action; BREAST-CANCER CELLS; RANDOMIZED CONTROLLED-TRIAL; ENDOTHELIAL NITRIC-OXIDE; MEMBRANE-BINDING-SITES; BETA MESSENGER-RNA; ER-BETA; POSTMENOPAUSAL WOMEN; GENE-EXPRESSION; MEDIATED NEUROPROTECTION; ESTRADIOL-MEMBRANE;
D O I
10.1016/j.bbagen.2010.04.011
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background: Estrogens are steroid hormones responsible for the primary and secondary sexual characteristics in females. While pre-menopausal women use estrogens as the main constituents of contraceptive pills, post-menopausal women use the same for Hormone Replacement Therapy. Estrogens produce reactive oxygen species by increasing mitochondrial activity and redox cycling of estrogen metabolites. The phenolic hydroxyl group present at the C3 position of the A ring of estrogens can get oxidized either by accepting an electron or by losing a proton. Thus, estrogens might act as pro-oxidant in some settings, resulting in complicated non-communicable diseases, namely, cancer and cardiovascular disorders. However, in some other settings the phenolic hydroxyl group of estrogens may be responsible for the anti-oxidative beneficial functions and thus protect against cardiovascular and neurodegenerative diseases. Scope of review: To date, no single review article has mentioned the implication of estrogen receptors in both the pro-oxidative and anti-oxidative actions of estrogens. Major conclusion: The controversial role of estrogens as pro-oxidant or anti-oxidant is largely dependent on cell types, ratio of different types of estrogen receptors present in a particular cell and context specificity of the estrogen hormone responses. Both pro-oxidant and anti-oxidant effects of estrogens might involve different estrogen receptors that can have either genomic or non-genomic action to manifest further hormonal response. General significance: This review highlights the role of estrogen receptors in the pro-oxidative and anti-oxidative actions of estrogens with special emphasis on neuronal cells. (C) 2010 Elsevier BM. All rights reserved.
引用
收藏
页码:1127 / 1135
页数:9
相关论文
共 50 条
  • [1] Resveratrol Regulates Pro-oxidative And Anti-oxidative Enzymes In The Cardiovascular System
    Xia, Ning
    Daiber, Andreas
    Habermeler, Alice
    Spanier, Gerrit
    Lu, Qing
    Oelze, Matthias
    Closs, Ellen I.
    Muenzel, Thomas
    Foerstermann, Ulrich
    Li, Huige
    [J]. CIRCULATION, 2008, 118 (18) : S417 - S417
  • [2] IN-VITRO ANTI-OXIDATIVE AND PRO-OXIDATIVE EFFECTS OF NATURAL POLYPHENOLS
    STADLER, RH
    MARKOVIC, J
    TURESKY, RJ
    [J]. BIOLOGICAL TRACE ELEMENT RESEARCH, 1995, 47 (1-3) : 299 - 305
  • [3] Lipid oxidation in poultry doner kebab: Pro-oxidative and anti-oxidative factors
    Kilic, B
    Richards, MP
    [J]. JOURNAL OF FOOD SCIENCE, 2003, 68 (02) : 686 - 689
  • [4] Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male fertility
    Garrido, N
    Meseguer, M
    Simon, C
    Pellicer, A
    Remohi, J
    [J]. ASIAN JOURNAL OF ANDROLOGY, 2004, 6 (01) : 59 - 65
  • [5] Inactivation of creatine kinase induced by quercetin with horseradish peroxidase and hydrogen peroxide: pro-oxidative and anti-oxidative actions of quercetin
    Miura, T
    Muraoka, S
    Fujimoto, Y
    [J]. FOOD AND CHEMICAL TOXICOLOGY, 2003, 41 (06) : 759 - 765
  • [6] Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male fertility
    Nicolás Garrido
    Marcos Meseguer
    Carlos Simon
    Antonio Pellicer
    José Remohi
    [J]. Asian Journal of Andrology, 2004, (01) : 59 - 65
  • [7] The Consequences of Hyperoxia in Acute vs Chronic Settings towards Pro-Oxidative and Anti-Oxidative Markers in Heart Tissue and Blood Plasma
    Alexsandro, Rio
    Limanan, David
    Yulianti, Eny
    Benettan, Renny
    Ferdinal, Frans
    [J]. EUROPEAN HEART JOURNAL SUPPLEMENTS, 2019, 21 (0F) : F89 - F89
  • [8] Anti-oxidative neuroprotection by estrogens in mouse cortical cultures
    Bae, YH
    Hwang, JY
    Kim, YH
    Koh, JY
    [J]. JOURNAL OF KOREAN MEDICAL SCIENCE, 2000, 15 (03) : 327 - 336
  • [9] Recent Trends in Composite Nanozymes and Their Pro-Oxidative Role in Therapeutics
    Maddheshiya, Shilpa
    Nara, Seema
    [J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022, 10
  • [10] Pro-oxidative and antioxidant effects of salicylates
    Zatko, Daniel
    Vaskova, Janka
    Perjesi, Pal
    Haus, Martin
    Vasko, Ladislav
    [J]. CHEMICAL PAPERS, 2020, 74 (09) : 3161 - 3168