Correlation of renal solute-free water reabsorption and energy of interaction of vasotocin analogs with V2 receptor

被引：1
|
作者：
Kutina, A. V. [1 ]
Karavashkina, T. A. [1 ]
Shakhmatova, E. I. [1 ]
Gao, J. [1 ]
Mordvintsev, D. Yu. [2 ]
Kuzmin, D. A. [2 ]
Tsetlin, V. I. [2 ]
Natochin, Yu. V. [1 ]
机构：
[1] Russian Acad Sci, IM Sechenov Evolutionary Physiol & Biochem Inst, St Petersburg 194223, Russia
[2] Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia
来源：
BIOLOGY BULLETIN | 2011年 / 38卷 / 06期
关键词：
V-1A VASOPRESSIN RECEPTOR; FROG URINARY-BLADDER; ARGININE-VASOPRESSIN; NEUROHYPOPHYSEAL HORMONES; NONPEPTIDE ANTAGONIST; MOLECULAR-CLONING; BINDING DOMAINS; LIGAND-BINDING; V1A RECEPTOR; OXYTOCIN;
D O I：
10.1134/S1062359011060057
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The nonapeptide-receptor interaction energy calculated from docking algorithms was compared with the effect of the same peptides upon solute-free water reabsorption in rat kidney in vivo. Vasotocin and some of its analogs were injected intramuscularly into conscious female Wistar rats in doses from 0.1 pmol to 0.5 nmol/kg of body weight after oral water load (50 ml/kg of body weight). A significant correlation was found between the calculated energy of peptide interaction with V-2 receptors and an increase in the renal solute-free water reabsorption stimulated by injection of nonapeptides. The results evidence that physiological changes in rat kidney in vivo induced by vasotocin analogs can be accurately simulated by virtual modeling of their interactions with V-2 receptors.
引用
收藏
页码：615 / 621
页数：7
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