Papuamides E and F, cytotoxic depsipeptides from the marine sponge Melophlus sp.

被引：27
|
作者：
Prasad, Pritesh [1 ]
Aalbersberg, William [1 ]
Feussner, Klaus-D. [1 ]
Van Wagoner, Ryan M. [2 ]
机构：
[1] Univ S Pacific, Fac Sci Technol & Environm, Inst Appl Sci, Suva, Fiji
[2] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA
来源：
TETRAHEDRON | 2011年 / 67卷 / 44期
关键词：
Papuamide; Melophlus; Depsipeptide; Cytotoxic; NEW-GUINEA; A-D; SARASSINORUM; MIRABILIS; SAPONINS;
D O I：
10.1016/j.tet.2011.08.100
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two known papuamides C (1) and D (2) together with two new depsipeptides, papuamides E (3) and F (4), were isolated from an undescribed sponge of the genus Melophlus collected in the Solomon Islands. The planar structures of the compounds were elucidated on the basis of spectroscopic studies. Papuamides C-F (1-4) showed cytotoxicity against brine shrimp with LD(50) values between 92 and 106 mu g/mL. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8529 / 8531
页数：3
相关论文
共 50 条
  • [1] Cytotoxic alkaloids from the marine sponge Thorectandra sp.
    Charan, RD
    Mckee, TC
    Boyd, MR
    NATURAL PRODUCT RESEARCH, 2004, 18 (03) : 225 - 229
  • [2] Cytotoxic polyacetylenes from the marine sponge Petrosia sp.
    Kim, JS
    Lim, YJ
    Im, KS
    Jung, JH
    Shim, CJ
    Lee, CO
    Hong, J
    Lee, H
    JOURNAL OF NATURAL PRODUCTS, 1999, 62 (04): : 554 - 559
  • [3] Cytotoxic oxylipins from a marine sponge Topsentia sp.
    Luo, X
    Li, FM
    Hong, JK
    Lee, CO
    Sim, CJ
    Im, KS
    Jung, JH
    JOURNAL OF NATURAL PRODUCTS, 2006, 69 (04): : 567 - 571
  • [4] Cytotoxic Petrosiacetylenes from the Marine Sponge Petrosia sp.
    Lee, Yeon-Ju
    Yoo, Su-Jung
    Kang, Jong Soon
    Yun, Jieun
    Shin, Hee Jae
    Lee, Jong Seok
    Lee, Hyi-Seung
    LIPIDS, 2013, 48 (01) : 87 - 91
  • [5] Cytotoxic furanosesterterpenes from a marine sponge Psammocinia sp.
    Choi, K
    Hong, JK
    Lee, CO
    Kim, DK
    Sim, CJ
    Im, KS
    Jung, JH
    JOURNAL OF NATURAL PRODUCTS, 2004, 67 (07): : 1186 - 1189
  • [6] Poecillastrin E, F, and G, cytotoxic chondropsin-type macrolides from a marine sponge Poecillastra sp.
    Irie, Raku
    Hitora, Yuki
    Ise, Yuji
    Okada, Shigeru
    Takada, Kentaro
    Matsunaga, Shigeki
    TETRAHEDRON, 2018, 74 (13) : 1430 - 1434
  • [7] Tasipeptins A and B:: New cytotoxic depsipeptides from the marine cyanobacterium Symploca sp.
    Williams, PG
    Yoshida, WY
    Moore, RE
    Paul, VJ
    JOURNAL OF NATURAL PRODUCTS, 2003, 66 (05): : 620 - 624
  • [8] Bacillibactins E and F from a Marine Sponge-Associated Bacillus sp.
    Wu, Qihao
    Throckmorton, Kurt
    Maity, Mitasree
    Chevrette, Marc G.
    Braun, Doug R.
    Rajski, Scott R.
    Currie, Cameron R.
    Thomas, Michael G.
    Bugni, Tim S.
    JOURNAL OF NATURAL PRODUCTS, 2021, 84 (01): : 136 - 141
  • [9] Callyspongiolide, a Cytotoxic Macrolide from the Marine Sponge Callyspongia sp.
    Cong-Dat Pham
    Hartmann, Rudolf
    Boehler, Philip
    Stork, Bjoern
    Wesselborg, Sebastian
    Lin, Wenhan
    Lai, Daowan
    Proksch, Peter
    ORGANIC LETTERS, 2014, 16 (01) : 266 - 269
  • [10] Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.
    Lee, Yeon-Ju
    Lee, Jeong-Woo
    Lee, Dong-Geun
    Lee, Hyi-Seung
    Kang, Jong Soon
    Yun, Jieun
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 15 (11): : 20045 - 20053
12345