Targeting nucleic acid secondary structures with polyamides using an optimized dynamic combinatorial approach

被引：46
|
作者：
Ladame, S [1 ]
Whitney, AM [1 ]
Balasubramanian, S [1 ]
机构：
[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 35期
基金：
英国生物技术与生命科学研究理事会;
关键词：
combinatorial chemistry; DNA recognition; DNA structures; nucleic acids; template synthesis;
D O I：
10.1002/anie.200501450
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Reversible disulfide chemistry is used to identify ligands that stabilize either duplex or quadruplex DNA secondary structures from a dynamic combinatorial library of polyamide building blocks (example structure shown). Double-stranded DNA induces a larger amplification than quadruplex DNA, in accordance with the selectivity of the ligands for each DNA target. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：5736 / 5739
页数：4
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