Deletions of 6q predominantly involve band q23 and distinguish Waldenstrom macruglobulinemia from IgM monoclonal gammopathy of undetermined significance.

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作者
Xu, RF
Van Wier, SA
Ghobrial, I
Schop, RFJ
Ahmann, GJ
Greipp, PR
Kyle, RA
Rajkumar, V
Gertz, MA
Fonseca, R
机构
[1] Mayo Clin & Mayo Fdn, Div Hematol Res, Rochester, MN 55905 USA
[2] Mayo Clin & Mayo Fdn, Dept Internal Med, Rochester, MN 55905 USA
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R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
2523
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页码:681A / 681A
页数:1
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  • [3] Deletions of 13q14 are already present in plasma cells from patients with monoclonal gammopathy of undetermined significance
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  • [4] Deletion of chromosome 13q is a frequent abnormality in multiple myeloma evolving from a preexisting monoclonal gammopathy of undetermined significance.
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  • [5] Deletions in 6q21-22 are commonly present in patients with familial and non-familial Waldenstrom's macroglobulinemia and IgM monoclonal gammopathy of unknown significance (MGUS).
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  • [6] Interphase fluorescence in situ hybridization reveals presence of 13q14 deletions in plasma cells from patients with monoclonal gammopathy of undetermined significance (MGUS).
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