Head and neck cancer in Australia between 1982 and 2005 show increasing incidence of potentially HPV-associated oropharyngeal cancers

被引:143
|
作者
Hocking, J. S. [1 ]
Stein, A. [2 ]
Conway, E. L. [2 ]
Regan, D. [3 ]
Grulich, A. [4 ]
Law, M. [3 ]
Brotherton, J. M. L. [5 ]
机构
[1] Univ Melbourne, Ctr Womens Hlth Gender & Soc, Carlton, Vic 3053, Australia
[2] CSL Ltd, Parkville, Vic 3052, Australia
[3] Univ New S Wales, Natl Ctr HIV Epidemiol & Clin Res, Coogee, NSW 2034, Australia
[4] Natl Ctr HIV Epidemiol & Clin Res, Darlinghurst, NSW 2010, Australia
[5] Natl HPV Vaccinat Program Register, Melbourne, Vic 3002, Australia
基金
澳大利亚研究理事会;
关键词
oropharyngeal cancer; human papillomavirus; oral cavity cancer; PAPILLOMAVIRUS-ASSOCIATED CANCERS; SQUAMOUS-CELL CARCINOMAS; ORAL SEXUAL-BEHAVIORS; REPRESENTATIVE SAMPLE; INTERNATIONAL HEAD; POOLED ANALYSIS; UNITED-STATES; SMOKING; RISK; EPIDEMIOLOGY;
D O I
10.1038/sj.bjc.6606091
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND: Although tobacco-and alcohol-associated head and neck cancers are declining in the developed world, potentially human papillomavirus (HPV)-associated oropharnygeal cancers are increasing. METHODS: We analysed oropharyngeal and oral cavity cancer rates in Australia in 1982-2005. Cancers from the oropharynx (base of tongue, tonsil and other specific oropharyngeal sites) were classified as potentially HPV associated (n = 8844); cancers in other oral cavity and oropharyngeal sites not previously associated with HPV were classified as comparison (n 28 379). RESULTS: In 2000-2005, an average of 219, 159 and 110 cancers of the tonsil, base of tongue and other oropharyngeal sites were diagnosed annually, with incidences of 1.09 (95% CI: 1.03, 1.15), 0.79 (95% CI: 0.74, 0.84) and 0.55 (95% CI: 0.50, 0.59) per 100 000, respectively. An average of 1242 comparison cancers were diagnosed annually (6.17 (95% CI: 6.03, 6.31) per 100 000). In 1982-2005, there were significant annual increases in tonsil (1.39% (95% CI: 0.88, 1.92%)) and base of tongue cancers in males (3.02% (95% CI: 2.27, 3.78%)) and base of tongue cancer in females (3.45% (95% CI: 2.21, 4.70%)). There was a significant decrease in comparison cancers in men (-1.69% (95% CI: -1.96, -1.42%)), but not in females. CONCLUSION: Potentially HPV-associated oropharyngeal cancer in Australia is increasing; the impact of HPV vaccination on these cancers should be monitored. British Journal of Cancer (2011) 104, 886-891. doi:10.1038/sj.bjc.6606091 www.bjcancer.com Published online 1 February 2011 (C) 2011 Cancer Research UK
引用
收藏
页码:886 / 891
页数:6
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