Perioperative anaesthetic management in cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC): a retrospective analysis in a single tertiary care cancer centre

被引:3
|
作者
Gupta, Raghav [1 ]
Gupta, Nishkarsh [1 ]
Sirohiya, Prashant [1 ]
Pandit, Anuja [1 ]
Ratre, Brajesh Kumar [1 ]
Vig, Saurabh [1 ]
Bhan, Swati [1 ]
Singh, Ram [1 ]
Kumar, Balbir [1 ]
Bhopale, Shweta [1 ]
Mishra, Seema [1 ]
Garg, Rakesh [1 ]
Bharati, Sachidanand Jee [1 ]
Kumar, Vinod [1 ]
Deo, Suryanarayana [2 ]
Bhatnagar, Sushma [1 ]
机构
[1] AIIMS, Dept Oncoanesthesia & Palliat Med, New Delhi 110029, India
[2] All India Inst Med Sci, Dept Surg Oncol, New Delhi, India
关键词
anaesthesia; cancer; cytoreductive surgery; fluid therapy; hyperthermic intraperitoneal chemotherapy; perioperative care; PERITONEAL CARCINOMATOSIS; HOSPITAL STAY; COMPLICATIONS; MORBIDITY; THERAPY; OUTCOMES; TRIAL;
D O I
10.1515/pp-2022-0001
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objectives: Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is associated with increased morbidity and mortality. We retrospectively analysed the perioperative anesthetic management in patients undergoing HIPEC surgery. Methods: After ethics approval, we reviewed the records of patients who underwent CRS/HIPEC from 2015 until 2020. We noted the peritoneal carcinomatosis index (PCI), blood loss, anastomoses done, total amount of fluid given, delta temperature and duration of surgery. These were correlated with the need for postoperative ventilation, length of ICU stay, Clavien-Dindo score and 30 day mortality. Results: Of the 180 patients reviewed, the majority were women (85%) with a mean age of 48 years who had ovarian tumors (n=114). The total amount of fluid given was associated with an increased length of ICU stay (p=0.008). Prolonged surgery resulted in increased length of ICU stay (p<0.001), need for postoperative ventilation (p=0.006) and a poor Clavien-Dindo score (p=0.039). A high PCI score correlated with increased ICU stay, 30 day mortality (p<0.001), and the need for postoperative ventilation (0.005). Conclusions: PCI, duration of surgery and blood loss were major predictors of postoperative morbidity. Additionally, the amount of fluid given and delta temperature affected patient outcome and should be individualized to the patient's needs.
引用
收藏
页码:127 / 134
页数:8
相关论文
共 50 条
  • [1] 201 consecutive cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) procedures in a single Asian tertiary centre
    Tan, Grace
    Chia, Claramae
    Kumar, Mrinal
    Choo, Su Pin
    Chia, John
    Tham, Chee Kian
    Chua, Clarinda
    Soo, Khee Chee
    Teo, Melissa
    [J]. INTERNATIONAL JOURNAL OF HYPERTHERMIA, 2017, 33 (03) : 288 - 294
  • [2] PERIOPERATIVE COMPLICATIONS AFTER CYTOREDUCTIVE SURGERY (CRS) AND HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY (HIPEC) - AN EXPERIENCE FROM THE TERTIARY CARE CENTRE IN NORTH INDIA
    Kumar, N.
    Ray, M. D.
    Deo, S.
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2020, 30 : A170 - A170
  • [3] Anaesthetic management and perioperative outcomes of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: A retrospective analysis
    Balakrishnan, Kalpana P.
    Survesan, Sreedevi
    [J]. INDIAN JOURNAL OF ANAESTHESIA, 2018, 62 (03) : 188 - 196
  • [4] Anaesthetic Considerations in the Perioperative Management of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
    Sheshadri D.B.
    Chakravarthy M.R.
    [J]. Indian Journal of Surgical Oncology, 2016, 7 (2) : 236 - 243
  • [5] Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Peritoneal Mesothelioma
    Tan, Grace H. C.
    Cheung, Michelle
    Chanyaputhipong, Jendana
    Soo, Khee Chee
    Teo, Melissa C. C.
    [J]. ANNALS ACADEMY OF MEDICINE SINGAPORE, 2013, 42 (06) : 291 - 296
  • [6] Colorectal peritoneal carcinomatosis treated with cytoreductive Surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC): The experience of a tertiary Asian centre
    Tan, G.
    Tham, C. K.
    Lim, C.
    Soo, K. C.
    Teo, M.
    [J]. EUROPEAN JOURNAL OF CANCER, 2013, 49 : S544 - S544
  • [7] Cytoreductive Reductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Recurrent Ovarian Cancer
    Tan, G.
    Chia, C.
    Teo, M.
    Soo, K. C.
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2016, 26 : 839 - 839
  • [8] Preliminary Experience and Morbidity Analysis of Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy (CRS/Hipec) from a Tertiary Cancer Center in India
    Padmanabhan, Naveen
    Kumar, Barath Raj
    Pookunju, Ansar Pullampara
    Srinivasan, Ayvapan
    Mahajan, Vikash
    [J]. JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2015, 9 (06) : XC9 - XC13
  • [9] Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in pseudomyxoma peritonei of appendiceal origin: result of a single centre study
    Di Leo, Alberto
    Corvasce, Arianna
    Weindelmayer, Jacopo
    Mason, Elena Jane
    Casella, Francesco
    de Manzoni, Giovanni
    [J]. UPDATES IN SURGERY, 2020, 72 (04) : 1207 - 1212
  • [10] Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in pseudomyxoma peritonei of appendiceal origin: result of a single centre study
    Alberto Di Leo
    Arianna Corvasce
    Jacopo Weindelmayer
    Elena Jane Mason
    Francesco Casella
    Giovanni de Manzoni
    [J]. Updates in Surgery, 2020, 72 : 1207 - 1212