Trimethoprim-Sulfamethoxazole Prophylaxis and Antibiotic Nonsusceptibility in Invasive Pneumococcal Disease

被引：16

作者：

Soeters, Heidi M. ^{[1
]}

von Gottberg, Anne ^{[3
]}

Cohen, Cheryl ^{[4
]}

Quan, Vanessa ^{[5
]}

Klugman, Keith P. ^{[2
,3
]}

机构：

[1] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA

[2] Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA 30322 USA

[3] Natl Inst Communicable Dis, Resp & Meningeal Pathogens Res Unit, Johannesburg, South Africa

[4] Natl Inst Communicable Dis, Epidemiol & Surveillance Unit, Johannesburg, South Africa

[5] Natl Inst Communicable Dis, Natl Microbiol Surveillance Unit, Johannesburg, South Africa

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 03期

关键词：

STREPTOCOCCUS-PNEUMONIAE; SOUTH-AFRICA; ANTIRETROVIRAL THERAPY; CHILDREN; HIV; COTRIMOXAZOLE; IMPACT; RESISTANCE; CARRIAGE; TRIAL;

D O I：

10.1128/AAC.05813-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Among 5,043 invasive pneumococcal disease (IPD) isolates identified through South African national surveillance from 2003 to 2007, we estimated the effect of trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis on antimicrobial resistance. Patients on TMP-SMX prophylaxis were more likely to have a pneumococcal isolate nonsusceptible to TMP-SMX, penicillin, and rifampin. TMP-SMX nonsusceptibility was associated with nonsusceptibility to penicillin, erythromycin, and rifampin and multidrug resistance. This study informs empirical treatment of suspected IPD in patients with a history of TMP-SMX use.

引用

页码：1602 / 1605

页数：4

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