Direct electrochemical behavior of the Cysteamine/DNA/SWNTs-film-modified Au electrode and its interaction with taxol

被引：19
|
作者：
Cheng, Wang Xing [1 ]
Peng, Dai Yin [1 ]
Lu, Chuan Hua [1 ]
Fang, Cheng Wu [1 ]
机构：
[1] Anhui Coll Tradit Chinese Med, Dept Pharmaceut, Hefei 230031, Peoples R China
来源：
RUSSIAN JOURNAL OF ELECTROCHEMISTRY | 2008年 / 44卷 / 09期
关键词：
single-wall carbon nanotubes; calf thymus DNA; cyclic voltammetry; modified electrode; taxol;
D O I：
10.1134/S1023193508090103
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
The Cysteamine/DNA/SWNTs-film-modified Au electrode was successfully prepared, and its electrochemical behavior is investigated by cyclic voltammetry (CV). The modified electrode exhibited a pair of stable and well-defined redox peaks, with the formal potentials (E-0) at about -0.032 V (vs. SCE) in 0.1 M pH 7.0 phosphate buffer solution (PBS). The dependence of E-0 on solution pH indicated that the direct electron transfer reaction of the Cysteamine/DNA/SWNTs film is the same electron transfer coupled with the proton participating in the reaction process. Taxol is an anticancer drug; it interacts with microtubule proteins in a manner that catalyzes the formation of microtubules from tubulin and stabilizes the resulting structures. Using the Cysteamine/DNA/SWNTs-film-modified Au electrode, we study the interaction between DNA and Taxol studied. A UV-Vis experiment is performed to confirm this interaction.
引用
收藏
页码：1052 / 1057
页数：6
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