Regioselective N9 alkylation of purine rings assisted by β-cyclodextrin

被引：13
|
作者：
Zhang, Qian [1 ]
Cheng, Gang [1 ]
Huang, Yong-Zhen [1 ]
Qu, Gui-Rong [1 ]
Niu, Hong-Ying [1 ]
Guo, Hai-Ming [1 ]
机构：
[1] Henan Normal Univ, Minist Educ, Coll Chem & Environm Sci, Key Lab Green Chem Media & React, Xinxiang 453007, Henan, Peoples R China
来源：
TETRAHEDRON | 2012年 / 68卷 / 38期
基金：
美国国家科学基金会;
关键词：
beta-Cyclodextrin; Purine; Alkylation; Selectivity; ANTIVIRAL ACTIVITY; HERPES GROUP; DERIVATIVES; NUCLEOSIDE; COMPLEXES; WATER; RECOGNITION; POTENT; AGENT; 9-(2-HYDROXYETHOXYMETHYL)GUANINE;
D O I：
10.1016/j.tet.2012.07.025
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Under the assistance of beta-cyclodextrin, purine was effectively alkylated at N9 together with up to 99% conversion and good to excellent yield using water as the solvent. High regioselectivity-N9/N7 selectivity>99:1 was attributed to the beta-cyclodextrin cavity blocked the N7 of purines ring. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7822 / 7826
页数：5
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