New borrelidin derivatives from an endophytic Streptomyces sp.

被引：6

作者：

Zhang, Li ^{[1
]}

Shi, Jing ^{[1
]}

Liu, Cheng Li ^{[1
]}

Xiang, Lang ^{[1
]}

Ma, Shi Ying ^{[1
]}

Li, Wei ^{[1
]}

Jiao, Rui Hua ^{[1
]}

Tan, Ren Xiang ^{[1
,2
]}

Ge, Hui Ming ^{[1
]}

机构：

[1] Nanjing Univ, Sch Life Sci, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China

[2] Nanjing Univ Chinese Med, State Key Lab Cultivat Base TCM Qual & Efficacy, Nanjing 210023, Jiangsu, Peoples R China

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 51期

关键词：

Borrelidin; Endophyte; Streptomyces sp; Antibacterial activity; Structure elucidation; ANGIOGENESIS INHIBITOR; BIOSYNTHESIS;

D O I：

10.1016/j.tetlet.2018.11.023

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new borrelidin-type macrolactones, designated as borrelidins J-L (4-6), together with borrelidin A (1), borrelidin E (2), and 12-desnitrile-12-carboxyl-borrelidin (3) were isolated from a plant endophytic Streptomyces sp. NA06554. Their structures were determined by extensive spectroscopic analysis including HRESIMS, 1D and 2D NMR data. The antibacterial activities for compounds 1-6 were examined. Borrelidins A (1) and L (6) showed potent and moderate antibacterial activity against Micrococcus luteus, respectively, whereas other derivatives (2-5) are almost inactive, which allows us to propose a plausible structure-activity relationship. (C) 2018 Elsevier Ltd. All rights reserved.

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页码：4517 / 4520

页数：4

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