Lactobacillus acidophilus Suppresses Colitis-Associated Activation of the IL-23/Th17 Axis

被引：75

作者：

Chen, Linlin ^{[1
]}

Zou, Yiyou ^{[1
]}

Peng, Jie ^{[1
]}

Lu, Fanggen ^{[2
]}

Yin, Yani ^{[1
]}

Li, Fujun ^{[1
]}

Yang, Junwen ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Gastroenterol, Changsha 410011, Hunan, Peoples R China

[2] Cent South Univ, Xiangya Hosp 2, Dept Gastroenterol, Changsha 410008, Hunan, Peoples R China

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2015年 / 2015卷

关键词：

INFLAMMATORY-BOWEL-DISEASE; TH17; CELLS; T-CELLS; IL-17; INTERLEUKIN-17; EXPRESSION; ALPHA; BETA; HOMEOSTASIS; CYTOKINES;

D O I：

10.1155/2015/909514

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aim of this paper is to determine the modulatory effects of Lactobacillus acidophilus on the IL-23/Th17 immune axis in experimental colitis. DSS-induced mouse models of UC were to be saline, hormones, and different concentrations of Lactobacillus acidophilus intervention. The expression of interleukin-(IL-) 17, tumor necrosis factor alpha(TNF alpha), IL-23, transforming growth factor beta 1(TGF beta 1), signal transducer and activator of transcription 3 (STAT3), and phosphorylated (p)-STAT3 was examined by RT-PCR, Western blotting, and immunohistochemical analysis. And the results showed that administration of L. acidophilus suppressed Th17 cell-mediated secretion of proinflammatory cytokine IL-17 through downregulation of IL-23 and TGF beta 1 expression and downstream phosphorylation of p-STAT3.

引用

页数：10

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