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Structural Transformation: Assembly of an Otherwise Inaccessible DNA Nanocage

被引：25
|
作者：
Li, Yulin [1 ]
Tian, Cheng [1 ]
Liu, Zhiyu [1 ]
Jiang, Wen [2 ,3 ]
Mao, Chengde [1 ]
机构：
[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
[2] Purdue Univ, Markey Ctr Struct Biol, W Lafayette, IN 47907 USA
[3] Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 20期
基金：
美国国家科学基金会;
关键词：
DNA nanocages; DNA structures; self-assembly; strand displacement; 3D DNA; NANOSTRUCTURES; TETRAHEDRON; POLYHEDRA; ORIGAMI;
D O I：
10.1002/anie.201500755
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A strategy of structural transformation for the assembly of DNA nanocages that can not be assembled directly is described. In this strategy, a precursor DNA nanocage is assembled first and then is isothermally transformed into a desired, complicated nanocage. A dramatic, conformational change accompanies the transformation. This strategy has been proven to be successful by native polyacrylamide gel electrophoresis (PAGE) and cryogenic electron microscopy (cryoEM) imaging. We expect that the strategy of structural transformation will be useful for the assembly of many otherwise inaccessible DNA nanostructures and help to increase the structural complexity of DNA nanocages.
引用
收藏
页码：5990 / 5993
页数：4
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