RETRACTED: MicroRNA-218 inhibits proliferation and invasion in ovarian cancer by targeting Runx2 (Retracted Article)

被引：29

作者：

Li, Na ^{[1
]}

Wang, Lufei ^{[2
]}

Tan, Guangyun ^{[3
]}

Guo, Zhiheng ^{[1
]}

Liu, Lei ^{[1
]}

Yang, Ming ^{[4
]}

He, Jin ^{[1
]}

机构：

[1] Jilin Univ, Dept Gynecol & Obstet, Hosp 1, Changchun 130021, Jilin, Peoples R China

[2] Jilin Univ, Dept Ophthalmol, Hosp 2, Changchun 130022, Jilin, Peoples R China

[3] Jilin Univ, Dept Immunol, Hosp 1, Inst Translat Med, Changchun 130021, Jilin, Peoples R China

[4] Jilin Univ, Dept Breast Surg, Hosp 1, Changchun 130021, Jilin, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 53期

关键词：

MiR-218; ovarian cancer; RUNX2; proliferation; invasion; TRANSCRIPTION FACTOR RUNX2; DOWN-REGULATION; TUMOR-GROWTH; MIR-218; PROGRESSION; EXPRESSION; CARCINOMA; DIFFERENTIATION; CISPLATIN; REGULATOR;

D O I：

10.18632/oncotarget.21069

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNA-218 (miR-218) has been implicated in the development and progression of multiple cancers. We investigated the role of miR-218 in ovarian cancer progression. We found that miR-218 expression levels were lower in ovarian cancer tissues and cell lines than in adjacent normal tissues or a normal ovarian cell line. miR-218 levels associated with International Federation of Gynecology and Obstetrics (FIGO) stage and lymph node metastasis. Exogenous expression of miR-218 inhibited cell proliferation, colony formation, migration, and invasion in vitro and suppressed tumor growth in a tumor-bearing nude mouse model. Runt-related transcription factor 2 (RUNX2) was identified as a direct functional target of miR-218, and its expression was inversely correlated with miR-218 expression in ovarian cancer tissues. RUNX2 overexpression rescued the suppressive effect of miR-218 on ovarian cancer cell proliferation, colony formation, migration, and invasion. These findings highlight an important role played bymiR-218 in the regulation of cancer growth and metastasis, in part by repressing RUNX2, and revealed the potential of miR-218 as a new therapeutic target inovarian cancer.

引用

页码：91530 / 91541

页数：12