Proliferative senescence in hematopoietic stem cells during ex-vivo expansion

被引：0

作者：

Piacibello, W ^{[1
]}

Gammaitoni, L ^{[1
]}

Pignochino, Y ^{[1
]}

机构：

[1] Univ Turin, IRCCS Inst Canc Res & Treatment, Lab Med Oncol, Dept Oncol Sci,Med Sch, I-10060 Turin, Italy

来源：

FOLIA HISTOCHEMICA ET CYTOBIOLOGICA | 2005年 / 43卷 / 04期

关键词：

hematopoietic stem cells; cell senescence; telomere shortening; ex vivo expansion; NOD/SCID mice; transplantation;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The good outcome of hematopoietic stem cell (HSC) transplantation is hampered by low doses of CD34(+) cell infusion. Transplanted HSCs undergo a replicative stress that causes accelerated senescence due to rapid telomere shortening. The expansion of human cord blood HSCs is instrumental in obtaining a large number of "good quality" cells, in terms of telomere length and telomerase activity compared to adult HSCs.

引用

页码：197 / 202

页数：6

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