Molarless-induced changes of spines in hippocampal region of SAMP8 mice

被引：43
|
作者：
Kubo, K
Iwaku, F
Watanabe, K
Fujita, M
Onozuka, M
机构：
[1] Asahi Univ, Sch Dent, Div Oral Struct Funct & Dev, Dept Oral Ant, Gifu 5010296, Japan
[2] Gifu Univ, Sch Med, Dept Physiol, Gifu 500, Japan
[3] Gifu Univ, Sch Med, Dept Anat & Neurosci, Gifu 500, Japan
[4] Kanagawa Dent Coll, Dept Physiol & Neurosci, Yokosuka, Kanagawa 238, Japan
来源：
BRAIN RESEARCH | 2005年 / 1057卷 / 1-2期
关键词：
masticatory dysfunction; spine; learning ability; hippocampus; SAMP8;
D O I：
10.1016/j.brainres.2005.07.038
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We examined the effect of the molarless condition on the dendritic spines of hippocampal pyramidal cells in SAMP8 mice in companson to its effect on learning ability in a maze test. The molarless condition caused a decrease in the number of the spines of CA1 pyramidal cells only in the aged mice showing a reduced learning ability. The results suggest the involvement of the molarless condition in an attenuation of input activities in the hippocampal synapses. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：191 / 195
页数：5
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