Suppression of Inflammatory Immune Responses in Celiac Disease by Experimental Hookworm Infection

被引:95
|
作者
McSorley, Henry J. [1 ,2 ]
Gaze, Soraya [1 ,2 ]
Daveson, James [3 ]
Jones, Dianne [3 ]
Anderson, Robert P. [4 ]
Clouston, Andrew [5 ]
Ruyssers, Nathalie E. [1 ,2 ]
Speare, Richard [1 ,2 ]
McCarthy, James S. [6 ]
Engwerda, Christian R. [6 ]
Croese, John [7 ]
Loukas, Alex [1 ,2 ]
机构
[1] James Cook Univ, Cairns, Qld, Australia
[2] James Cook Univ, Townsville, Qld 4811, Australia
[3] Princess Alexandra Hosp, Brisbane, Qld 4102, Australia
[4] Walter & Eliza Hall Inst Med Res, Melbourne, Australia
[5] Envoi Specialist Pathologists, Brisbane, Qld, Australia
[6] Univ Queensland, Queensland Inst Med Res, Brisbane, Qld, Australia
[7] Townsville Hosp, Townsville, Qld, Australia
来源
PLOS ONE | 2011年 / 6卷 / 09期
基金
英国医学研究理事会;
关键词
REGULATORY T-CELLS; NECATOR-AMERICANUS; PARASITE INFECTION; CHILDREN; INTERLEUKIN-10; EXPANSION; CYTOKINES; ETHIOPIA; PEPTIDE; GLIADIN;
D O I
10.1371/journal.pone.0024092
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We present immunological data from two clinical trials where the effect of experimental human hookworm (Necator americanus) infection on the pathology of celiac disease was evaluated. We found that basal production of Interferon-(IFN-)gamma and Interleukin- (IL-)17A from duodenal biopsy culture was suppressed in hookworm-infected participants compared to uninfected controls. Increased levels of CD4+CD25+Foxp3+cells in the circulation and mucosa are associated with active celiac disease. We show that this accumulation also occurs during a short-term (1 week) oral gluten challenge, and that hookworm infection suppressed the increase of circulating CD4+CD25+Foxp3+cells during this challenge period. When duodenal biopsies from hookworm-infected participants were restimulated with the immunodominant gliadin peptide QE65, robust production of IL-2, IFN-gamma and IL-17A was detected, even prior to gluten challenge while participants were strictly adhering to a gluten-free diet. Intriguingly, IL-5 was produced only after hookworm infection in response to QE65. Thus we hypothesise that hookworm-induced TH2 and IL-10 cross-regulation of the TH1/TH17 inflammatory response may be responsible for the suppression of these responses during experimental hookworm infection.
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页数:7
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