Podocyte Aging: Why and How Getting Old Matters

被引：2

作者：

Shankland, Stuart J. ^{[1
,2
]}

Wang, Yuliang ^{[2
,3
]}

Shaw, Andrey S. ^{[4
]}

Vaughan, Joshua C. ^{[5
,6
]}

Pippin, Jeffrey W. ^{[1
]}

Wessely, Oliver ^{[7
]}

机构：

[1] Univ Washington, Div Nephrol, Seattle, WA USA

[2] Univ Washington, Inst Stem Cell & Regenerat Med, Seattle, WA USA

[3] Univ Washington, Paul G Allen Sch Comp Sci & Engn, Seattle, WA USA

[4] Genentech Inc, Dept Biol Res, South San Francisco, CA USA

[5] Univ Washington, Dept Chem, Seattle, WA USA

[6] Univ Washington, Dept Physiol & Biophys, Seattle, WA USA

[7] Cleveland Clin Fdn, Lerner Res Inst, Dept Cardiovasc & Metab Sci, 9500 Euclid Ave NC10, Cleveland, OH 44195 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2021年 / 32卷 / 11期

关键词：

podocyte; aging; glomerulosclerosis; senescence; RNA sequencing; glomerulus; CYCLE INHIBITOR P16(INK4A); GLOMERULAR-FILTRATION-RATE; PARIETAL EPITHELIAL-CELLS; FATTY-ACID OXIDATION; DIABETIC-NEPHROPATHY; FUNCTIONAL-CHANGES; KIDNEY-DISEASE; MITOCHONDRIAL BIOGENESIS; PROGNOSTIC-FACTORS; SEXUAL-DIMORPHISM;

D O I：

10.1681/ASN.2021050614

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of healthy aging on the kidney, and how these effects intersect with superimposed diseases, are highly relevant in the context of the population?s increasing longevity. Age-associated changes to podocytes, which are terminally differentiated glomerular epithelial cells, adversely affect kidney health. This review discusses the molecular and cellular mechanisms underlying podocyte aging, how these mechanisms might be augmented by disease in the aged kidney, and approaches to mitigate progressive damage to podocytes. Furthermore, we address how biologic pathways such as those associated with cellular growth confound aging in humans and rodents.

引用

页码：2697 / 2713

页数：17

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