Perceived stress in prodromal Huntington disease

被引：20

作者：

Downing, Nancy ^{[2
]}

Smith, Megan M. ^{[1
]}

Beglinger, Leigh J. ^{[1
]}

Mills, James ^{[1
]}

Duff, Kevin ^{[3
]}

Rowe, Kelly C. ^{[1
,4
]}

Epping, Eric ^{[1
]}

Paulsen, Jane S. ^{[1
,5
,6
]}

机构：

[1] Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA

[2] Univ Iowa, Coll Nursing, Iowa City, IA 52242 USA

[3] Univ Utah, Dept Neurol, Salt Lake City, UT 84108 USA

[4] Univ Iowa, Interdept Neurosci Program, Iowa City, IA 52242 USA

[5] Univ Iowa, Dept Psychol, Iowa City, IA 52242 USA

[6] Univ Iowa, Dept Neurol, Iowa City, IA 52242 USA

来源：

PSYCHOLOGY & HEALTH | 2012年 / 27卷 / 02期

关键词：

Huntington disease; perceived stress; depression; QUALITY-OF-LIFE; DEPRESSION; HEALTH; IMPACT; MANIFESTATIONS; PREDICTION; DIAGNOSIS; MUTATION; 3-YEAR; MODEL;

D O I：

10.1080/08870446.2010.529141

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This study examines perceived stress and its relationship to depressive symptoms, life changes and functional capacity in a large sample of individuals who are positive for the Huntington disease (HD) gene expansion but not yet diagnosed. Participants were classified by estimated proximity to HD diagnosis (far, mid, near) and compared with a non-gene-expanded comparison group. Persons in the mid group had the highest stress scores. A significant interaction between age and time since HD genetic testing was also found. Secondary analyses using data from a different data collection point and including a diagnosed group showed the highest stress scores in the diagnosed group. Possible explanations and implications are discussed.

引用

页码：196 / 209

页数：14

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