Involvement of gonadotropins in the induction of hypertrophy-hyperplasia in the interstitial tissues of ovaries in neonatally diethylstilbestrol-treated mice

被引：11
|
作者：
Kakuta, Hanako [1 ]
Tanaka, Masami [2 ]
Chambon, Pierre [3 ]
Watanabe, Hajime [4 ,5 ]
Iguchi, Taisen [4 ,5 ]
Sato, Tomomi [1 ]
机构：
[1] Yokohama City Univ, Int Grad Sch Arts & Sci, Yokohama, Kanagawa 2360027, Japan
[2] St Marianna Univ, Dept Pharmacol, Sch Med, Kawasaki, Kanagawa 2168511, Japan
[3] CNRS INSERM ULP, Coll France, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France
[4] Grad Univ Adv Studies, Okazaki, Aichi 4448787, Japan
[5] Natl Inst Nat Sci, Natl Inst Basic Biol, Okazaki Inst Integrat Biosci, Okazaki, Aichi 4448787, Japan
来源：
REPRODUCTIVE TOXICOLOGY | 2012年 / 33卷 / 01期
关键词：
Ovary; DES; Steroiclogenesis; Interstitial cells; ACUTE REGULATORY PROTEIN; ESTROGEN-RECEPTOR-ALPHA; STEROIDOGENIC FACTOR-I; ORPHAN NUCLEAR RECEPTOR; KNOCKOUT MICE; FEMALE MICE; REPRODUCTIVE PHENOTYPES; POLYOVULAR FOLLICLES; TARGETED DISRUPTION; GENE-EXPRESSION;
D O I：
10.1016/j.reprotox.2011.10.013
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Neonatally diethylstilbestrol (DES) treatment causes hypertrophy-hyperplasia in the interstitial tissue of mouse ovaries. To understand the induction mechanism of the hypertrophy, mRNA expression involved in steroidogenesis in the ovary of neonatally DES-treated mice was examined. The expression of StAR and Cyp11a1 was significantly reduced while Cyp19 and Sf-1 were stimulated in the ovary of neonatally DES-treated 3-month-old mice. Expression of those genes was not different between DES- and oil-treated mice after the gonadotropins treatment. Lhb in the pituitary of 3-month-old neonatally DES-treated mice was significantly decreased. Finally, ovaries from DES-treated mice transplanted to neonatally oil-treated hosts had developing follicles at several stages and corpora lutea, whereas grafted ovaries from neonatally oil-treated mice in 3-month-old neonatally DES-treated hosts showed lipid accumulation in the interstitial tissue. Thus, hypertrophy and accumulation of lipid droplets in interstitial cells of neonatally DES-treated mice is caused by impaired steroidogenesis due to the alterations of gonadotropins levels. (C) 2011 Elsevier Inc. All rights reserved.
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收藏
页码：35 / 44
页数：10
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