Neurotoxic, hemorrhagic and proteolytic activities of Duvernoy's gland secretion from Venezuelan opisthoglyphous colubrid snakes in mice

被引：0
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作者：
Lemoine, K
Salgueiro, LM
Rodríguez-Acosta, A
Acosta, JA
机构：
[1] Cent Univ Venezuela, Inst Trop Med, Immunochem Sect, Caracas 1041, Venezuela
[2] Harvard Univ, Sch Med, Lab Translat Res, Cambridge, MA 02139 USA
来源：
VETERINARY AND HUMAN TOXICOLOGY | 2004年 / 46卷 / 01期
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D O I：
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中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Many colubrid snakes produce toxic oral secretions. We studied venom (Duvernoy's gland secretion) collected from Venezuelan opisthoglyphous (rear-fanged) colubrid snakes. Different proteins were present in Thamnodynastes stigilis Duvernoy's gland secretion and were characterized by 20% SDS-PAGE protein electrophoresis. The venom displayed proteo tic, (gelatinase) activity that was partially purified on-a chromatography ionic exchange mono Q2 column. We demonstrated hemorrhagic activity of Thamnodynastes stigilis Duvernoy's gland secretion on chicken embryos and mouse skin and peritoneum. Mice inoculated with Thamnodynastes stigilis Duvernoy's gland secretion presented signs of neurotoxicity. Thamnodynastes stigilis Duvernoy's gland secretion had proteo tic, hemorrhagic, and neurotoxic activities, not previous described in this species and identifies the presence of a new venomous colubrid in Venezuela.
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页码：10 / 14
页数：5
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