Noncoding RNAs Controlling Telomere Homeostasis in Senescence and Aging

被引：25
|
作者：
Rossi, Martina [1 ]
Gorospe, Myriam [1 ]
机构：
[1] NIA, Lab Genet & Genom, Intramural Res Program, NIH, Baltimore, MD 21224 USA
来源：
TRENDS IN MOLECULAR MEDICINE | 2020年 / 26卷 / 04期
基金：
美国国家卫生研究院;
关键词：
REPEAT-CONTAINING RNA; CELLULAR SENESCENCE; GENE-EXPRESSION; BREAST-CANCER; CELLS; TERRA; DNA; MICRORNAS; PROTEIN; TRANSCRIPTION;
D O I：
10.1016/j.molmed.2020.01.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aging is a universal and time-dependent biological decline associated with progressive deterioration of cells, tissues, and organs. Age-related decay can eventually lead to pathology such as cardiovascular and neurodegenerative diseases, cancer, and diabetes. A prominent molecular process underlying aging is the progressive shortening of telomeres, the structures that protect the ends of chromosomes, eventually triggering cellular senescence. Noncoding (nc)RNAs are emerging as major regulators of telomere length homeostasis. In this review, we describe the impact of ncRNAs on telomere function and discuss their implications in senescence and age-related diseases. We discuss emerging therapeutic strategies targeting telomere-regulatory ncRNAs in aging pathology. © 2020
引用
收藏
页码：422 / 433
页数：12
相关论文
共 50 条
  • [1] Noncoding RNAs in Cardiovascular Aging
    Li, Yongqin
    Zhu, Yujiao
    Li, Guoping
    Xiao, Junjie
    AGING AND AGING-RELATED DISEASES: MECHANISMS AND INTERVENTIONS, 2018, 1086 : 37 - 53
  • [2] Noncoding RNAs in Vascular Aging
    Cao, Qidong
    Wu, Jiuping
    Wang, Xiaoli
    Song, Chunli
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2020, 2020
  • [3] Small noncoding RNAs controlling pathogenesis
    Toledo-Arana, Alejandro
    Repoila, Francis
    Cossart, Pascale
    CURRENT OPINION IN MICROBIOLOGY, 2007, 10 (02) : 182 - 188
  • [4] Long noncoding RNAs in intestinal epithelium homeostasis
    Xiao, Lan
    Gorospe, Myriam
    Wang, Jian-Ying
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2019, 317 (01): : C93 - C100
  • [5] Long noncoding RNAs in diseases of aging
    Kim, Jiyoung
    Kim, Kyoung Mi
    Noh, Ji Heon
    Yoon, Je-Hyun
    Abdelmohsen, Kotb
    Gorospe, Myriam
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2016, 1859 (01): : 209 - 221
  • [6] Roles of long noncoding RNAs in aging and aging complications
    Jin, Ling
    Song, Qirui
    Zhang, Weili
    Geng, Bin
    Cai, Jun
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2019, 1865 (07): : 1763 - 1771
  • [7] Noncoding RNAs Controlling Oxidative Stress in Cancer
    Holvoet, Paul
    CANCERS, 2023, 15 (04)
  • [8] Controlling transcription with noncoding RNAs in mammalian cells
    Turner, Anne-Marie W.
    Morris, Kevin V.
    BIOTECHNIQUES, 2010, 48 (06) : IX - +
  • [9] The Impact of Long Noncoding RNAs in Tissue Regeneration and Senescence
    Silva, Julia Tavares e
    Pessoa, Joao
    Nobrega-Pereira, Sandrina
    de Jesus, Bruno Bernardes
    CELLS, 2024, 13 (02)
  • [10] Senescence-associated lncRNAs: senescence-associated long noncoding RNAs
    Abdelmohsen, Kotb
    Panda, Amaresh
    Kang, Min-Ju
    Xu, Jason
    Selimyan, Roza
    Yoon, Je-Hyun
    Martindale, Jennifer L.
    De, Supriyo
    Wood, William H., III
    Becker, Kevin G.
    Gorospe, Myriam
    AGING CELL, 2013, 12 (05) : 890 - 900
12345