HIV-1 Infection Results in Increased Frequency of Active and Inflammatory SlanDCs that Produce High Level of IL-1β

被引：12

作者：

Tufa, Dejene M. ^{[1
]}

Ahmad, Fareed ^{[1
]}

Chatterjee, Debanjana ^{[1
]}

Ahrenstorf, Gerrit ^{[1
]}

Schmidt, Reinhold E. ^{[1
]}

Jacobs, Roland ^{[1
]}

机构：

[1] Hannover Med Sch MHH, Dept Clin Immunol & Rheumatol, Hannover, Germany

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2016年 / 73卷 / 01期

关键词：

HIV; slanDCs; IL-1; beta; DENDRITIC CELLS; 6-SULFO LACNAC; TNF-ALPHA; NK CELLS; BLOOD; INTERLEUKIN-1; MACROPHAGES; POPULATION; ACTIVATION; DISEASE;

D O I：

10.1097/QAI.0000000000001082

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV infection is marked by phenotypic and functional alterations of immune cells. Different studies have shown both numerical and functional deterioration of dendritic cells in HIV-1-infected patients. In this study, we report an increase of inflammatory 6-sulfo LacNAc dendritic cells (slanDCs) that are more activated and produce higher amounts of interleukin (IL)-1 during HIV-1 infection as compared with healthy controls. IL-1 plays a regulatory role in chronic inflammatory disorders. Therefore, our findings might reveal a compensatory regulatory function of slanDCs during HIV-1 infection.

引用

页码：34 / 38

页数：5

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