Necroptosis: An emerging form of programmed cell death

被引：198
|
作者：
Wu, Wei [1 ]
Liu, Peng [1 ]
Li, Jianyong [1 ]
机构：
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Hematol, Nanjing 210029, Jiangsu, Peoples R China
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2012年 / 82卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Necroptosis; Apoptosis; Cell death; Cancer; TUMOR-NECROSIS-FACTOR; RECEPTOR-INTERACTING PROTEIN; MITOCHONDRIAL PERMEABILITY TRANSITION; CYTOSOLIC PHOSPHOLIPASE A(2); KAPPA-B ACTIVATION; NITRIC-OXIDE; CYCLOPHILIN-D; FACTOR-ALPHA; NADPH OXIDASE; RIP KINASES;
D O I：
10.1016/j.critrevonc.2011.08.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Necrosis plays an important role in multiple physiological and pathological processes. Recently, a relatively new form of necrosis has been characterized as "necroptosis". Morphologically, necroptosis exhibits the features of necrosis; however, necroptosis exhibits a unique signaling pathway that requires the involvement of receptor interaction protein kinase 1 and 3 (RIP1 and RIP3) and can be specifically inhibited by necrostatins. Necroptosis has been found to contribute to the regulation of immune system, cancer development as well as cellular responses to multiple stresses. In this review, we will summarize the signaling pathway, biological effects and pathological significance of this specific form of programmed cell death. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：249 / 258
页数：10
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