The Cellular and Molecular Immunotherapy in Prostate Cancer

被引:15
|
作者
Mukherjee, Anirban Goutam [1 ]
Wanjari, Uddesh Ramesh [1 ]
Prabakaran, D. S. [2 ,3 ]
Ganesan, Raja [4 ]
Renu, Kaviyarasi [5 ]
Dey, Abhijit [6 ]
Vellingiri, Balachandar [7 ]
Kandasamy, Sabariswaran [8 ]
Ramesh, Thiyagarajan [9 ]
Gopalakrishnan, Abilash Valsala [1 ]
机构
[1] Vellore Inst Technol VIT, Sch Biosci & Technol, Dept BioMed Sci, Vellore 632014, Tamil Nadu, India
[2] Chungbuk Natl Univ, Coll Med, Dept Radiat Oncol, Chungdae Ro 1, Cheongju 28644, South Korea
[3] Ayya Nadar Janaki Ammal Coll, Dept Biotechnol, Srivilliputhur Main Rd, Sivakasi 626124, Tamil Nadu, India
[4] Hallym Univ, Inst Liver & Digest Dis, Chunchon 24252, South Korea
[5] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Dent Coll & Hosp, Ctr Mol Med & Diagnost COMManD,Dept Biochem, Chennai 600077, Tamil Nadu, India
[6] Presidency Univ, Dept Life Sci, Kolkata 700073, West Bengal, India
[7] Bharathiar Univ, Dept Human Genet & Mol Biol, Human Mol Cytogenet & Stem Cell Lab, Coimbatore 641046, Tamil Nadu, India
[8] Univ Seoul, Dept Environm Engn, Water Energy Nexus Lab, Seoul 02504, South Korea
[9] Prince Sattam bin Abdulaziz Univ, Coll Med, Dept Basic Med Sci, POB 173, Al Kharj 11942, Saudi Arabia
关键词
prostate cancer; immunotherapy; combination immunotherapy; immune checkpoints; biomarkers; DNA HYPOMETHYLATION; IMMUNE CHECKPOINTS; PROMISING TARGET; PATHOLOGY; CELLS; VISTA; HYPERMETHYLATION; METHYLATION; PROGRESSION; IPILIMUMAB;
D O I
10.3390/vaccines10081370
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In recent history, immunotherapy has become a viable cancer therapeutic option. However, over many years, its tenets have changed, and it now comprises a range of cancer-focused immunotherapies. Clinical trials are currently looking into monotherapies or combinations of medicines that include immune checkpoint inhibitors (ICI), CART cells, DNA vaccines targeting viruses, and adoptive cellular therapy. According to ongoing studies, the discipline should progress by incorporating patient-tailored immunotherapy, immune checkpoint blockers, other immunotherapeutic medications, hormone therapy, radiotherapy, and chemotherapy. Despite significantly increasing morbidity, immunotherapy can intensify the therapeutic effect and enhance immune responses. The findings for the immunotherapy treatment of advanced prostate cancer (PCa) are compiled in this study, showing that is possible to investigate the current state of immunotherapy, covering new findings, PCa treatment techniques, and research perspectives in the field's unceasing evolution.
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页数:16
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