Clinical Isolate of a Multi-Antifungal-Resistant Trichophyton rubrum

被引：17
|
作者：
Kano, Rui [1 ,2 ]
Kimura, Utako [3 ]
Noguchi, Hiromitsu [4 ,5 ]
Hiruma, Masataro [5 ]
机构：
[1] Nihon Univ, Coll Bioresource Sci, Dept Vet Dermatol, Fujisawa, Kanagawa, Japan
[2] Teikyo Univ, Inst Med Mycol TIMM, Hachioji, Tokyo, Japan
[3] Juntendo Univ, Urayasu Hosp, Dept Dermatol, Urayasu, Chiba, Japan
[4] Ochanomizu Inst Med Mycol & Allergol, Toshima Ku, Tokyo, Japan
[5] Noguchi Dermatol Clin, Kumamoto, Japan
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2022年 / 66卷 / 04期
关键词：
deletion mutation; onychomycosis; squalene epoxidase; terbinafine; Trichophyton rubrum; azole; dermatophytes; dermatophytoses;
D O I：
10.1128/aac.02393-21
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The multi-antifungal drug-resistant strain (NUBS21012) of Trichophyton rubrum was isolated from a patient with recurrent tinea corporis. The resistant strain encoded Phe at codon 393 instead of Leu (L393F) in the squalene epoxidase (SQLE) gene. The expression of genes encoding ATP-binding cassette transporter proteins increased in the strain compared to that of other strains. This result provides evidence that ATP-binding cassette transporter proteins are closely associated with azole resistance.
引用
收藏
页数：3
相关论文
共 50 条
  • [1] Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine
    Osborne, CS
    Leitner, I
    Hofbauer, B
    Fielding, CA
    Favre, B
    Ryder, NS
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (06) : 2234 - 2236
  • [2] Investigation of the antifungal potential of linalool against clinical isolates of fluconazole resistant Trichophyton rubrum
    de Oliveira Lima, M. I.
    Araujo de Medeiros, A. C.
    Souza Silva, K. V.
    Cardoso, G. N.
    de Oliveira Lima, E.
    de Oliveira Pereira, F.
    JOURNAL DE MYCOLOGIE MEDICALE, 2017, 27 (02): : 195 - 202
  • [3] Genome sequence of a clinical isolate of dermatophyte, Trichophyton rubrum from India
    Latka, Chitra
    Dey, Sanchita Sanchaya
    Mahajan, Siddharth
    Prabu, Ramachandira
    Jangir, Pramod Kumar
    Gupta, Chhavi
    Das, Shukla
    Ramachandran, Vishnampettai Ganapathysubramanian
    Bhattacharya, Sambit Nath
    Pandey, Rajesh
    Sharma, Rakesh
    Ramachandran, Srinivasan
    Taneja, Bhupesh
    FEMS MICROBIOLOGY LETTERS, 2015, 362 (08)
  • [4] Determination of Hemolytic Activity and In Vitro Antifungal Susceptibility of Trichophyton rubrum Clinical Strains
    Solgun, Gulkan
    Findik, Duygu
    Dagi, Hatice Turk
    Arslan, Ugur
    MIKROBIYOLOJI BULTENI, 2011, 45 (01): : 159 - 167
  • [5] Antifungal activity of chitooligosaccharides against the dermatophyte Trichophyton rubrum
    Mei, Yu-xia
    Dai, Xing-yi
    Yang, Wei
    Xu, Xiong-wei
    Liang, Yun-xiang
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2015, 77 : 330 - 335
  • [6] Cytotoxicity and Antifungal Properties of Hydroxychavicol Against Trichophyton rubrum
    Ridzuan, P. M.
    Mohamad, Nasir
    Ismail, Salwani
    Rahman, Nor Iza A.
    Aini, Hairul H.
    Zunariah, B.
    Norazian, M. H.
    Roesnita, Baharudin
    INTERNATIONAL MEDICAL JOURNAL MALAYSIA, 2018, 17 (01) : 39 - 44
  • [7] Comparison of Two Methods for Antifungal Susceptibility Testing of Trichophyton rubrum
    B. Fernández-Torres
    M. Pereiro
    J. Guarro
    European Journal of Clinical Microbiology and Infectious Diseases, 2002, 21 : 70 - 71
  • [8] Regional Differences in Antifungal Susceptibility of the Prevalent Dermatophyte Trichophyton rubrum
    Jiang, Y.
    Luo, W.
    Verweij, P. E.
    Song, Y.
    Zhang, B.
    Shang, Z.
    Al-Hatmi, A. M. S.
    Ahmed, S. A.
    Wan, Z.
    Li, R.
    de Hoog, G. S.
    MYCOPATHOLOGIA, 2021, 186 (01) : 53 - 70
  • [9] Regional Differences in Antifungal Susceptibility of the Prevalent Dermatophyte Trichophyton rubrum
    Y. Jiang
    W. Luo
    P. E. Verweij
    Y. Song
    B. Zhang
    Z. Shang
    A. M. S. Al-Hatmi
    S. A. Ahmed
    Z. Wan
    R. Li
    G. S. de Hoog
    Mycopathologia, 2021, 186 : 53 - 70
  • [10] Pothomorphe umbellata: Antifungal activity against strains of Trichophyton rubrum
    Rodrigues, E. R.
    Nogueira, N. G. P.
    Zocolo, G. J.
    Leite, F. S.
    Januario, A. H.
    Fusco-Almeida, A. M.
    Fachin, A. L.
    de Marchi, M. R. R.
    dos Santos, A. G.
    Pietro, R. C. L. R.
    JOURNAL DE MYCOLOGIE MEDICALE, 2012, 22 (03): : 265 - 269
12345