Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours

被引：3

作者：

Chye, Yann ^{[1
,2
]}

Suo, Chao ^{[1
,2
]}

Romero-Garcia, Rafael ^{[3
]}

Bethlehem, Richard A., I ^{[3
]}

Hook, Roxanne ^{[3
]}

Tiego, Jeggan ^{[2
,4
]}

Goodyer, Ian ^{[3
]}

Jones, Peter B. ^{[3
]}

Dolan, Ray ^{[5
,6
]}

Bullmore, Edward T. ^{[3
]}

Grant, Jon E. ^{[7
]}

Yucel, Murat ^{[1
,2
]}

Chamberlain, Samuel R. ^{[3
,8
,9
,10
]}

机构：

[1] Monash Univ, Sch Psychol Sci, Turner Inst Brain & Mental Hlth, BrainPk, Melbourne, Vic, Australia

[2] Monash Univ, Monash Biomed Imaging Facil, Melbourne, Vic, Australia

[3] Univ Cambridge, Dept Psychiat, Cambridge, England

[4] Monash Univ, Sch Psychol Sci, Turner Inst Brain & Mental Hlth, Neural Syst & Behav Lab, Melbourne, Vic, Australia

[5] Max Planck Univ Coll London, Ctr Computat Psychiat & Ageing Res, London, England

[6] UCL, Wellcome Ctr Human Neuroimaging, London, England

[7] Univ Chicago, Dept Psychiat, Chicago, IL 60637 USA

[8] Univ Southampton, Fac Med, Dept Psychiat, Southampton, Hants, England

[9] Southern Hlth NHS Fdn Trust, Southampton, Hants, England

[10] Cambridgeshire & Peterborough NHS Fdn Trust, Fulbourn, England

来源：

BRITISH JOURNAL OF PSYCHIATRY | 2022年 / 220卷 / 02期

基金：

英国惠康基金;

关键词：

Impulsivity; compulsivity; brain network; connectome; transdiagnostic;

D O I：

10.1192/bjp.2021.49

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Impulsive and compulsive problem behaviours are associated with a variety of mental disorders. Latent phenotyping indicates the expression of impulsive and compulsive problem behaviours is predominantly governed by a transdiagnostic 'disinhibition' phenotype. In a cohort of 117 individuals, recruited as part of the Neuroscience in Psychiatry Network (NSPN), we examined how brain functional connectome and network properties relate to disinhibition. Reduced functional connectivity within a subnetwork of frontal (especially right inferior frontal gyrus), occipital and parietal regions was linked to disinhibition. Findings provide insights into neurobiological pathways underlying the emergence of impulsive and compulsive disorders.

引用

页码：76 / 78

页数：3

共 11 条

[1] Brain micro-architecture and disinhibition: a latent phenotyping study across 33 impulsive and compulsive behaviours
Rafa Romero-Garcia
Roxanne W. Hook
Jeggan Tiego
Richard A. I. Bethlehem
Ian M. Goodyer
Peter B. Jones
Ray Dolan
Jon E. Grant
Edward T. Bullmore
Murat Yücel
Samuel R. Chamberlain
Neuropsychopharmacology, 2021, 46 : 423 - 431
[2] Brain micro-architecture and disinhibition: a latent phenotyping study across 33 impulsive and compulsive behaviours
Romero-Garcia, Rafa
Hook, Roxanne W.
Tiego, Jeggan
Bethlehem, Richard A. I.
Goodyer, Ian M.
Jones, Peter B.
Dolan, Ray
Grant, Jon E.
Bullmore, Edward T.
Yucel, Murat
Chamberlain, Samuel R.
NEUROPSYCHOPHARMACOLOGY, 2021, 46 (02) : 423 - 431
[3] Brain structural and functional signatures of impulsive–compulsive behaviours in Parkinson’s disease
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[10] Altered Functional Connectivity Across Large-Scale Brain Networks Predicts Attentional Control Deficits and Response to Cognitive-Behavioral Therapy in Pediatric Obsessive-Compulsive Disorder
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