Histone proteins are subject to modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, and ADP ribosylation, some of which are known to play important roles in the regulation of chromatin structure and function. Here we report that histone H4 is modified by small ubiquitin-related modifier (SUMO) family proteins both in vivo and in vitro. H4 binds to the SUMO-conjugating enzyme (E2), UBC9, and can be sumoylated in an E1 (SUMO-activating enzyme)- and E2-dependent manner. We present evidence suggesting that histone sumoylation mediates gene silencing through recruitment of histone deacetylase and heterochromatin protein 1.
机构:
Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China
Natl Taiwan Univ, Inst Plant Biol, Taipei 10764, TaiwanChinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China
Liu, Xuncheng
Yang, Songguang
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Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R ChinaChinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China
Yang, Songguang
Zhao, Minglei
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Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China
Univ Chinese Acad Sci, Beijing 100049, Peoples R ChinaChinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China
Zhao, Minglei
Luo, Ming
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Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R ChinaChinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China
Luo, Ming
Yu, Chun-Wei
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Natl Taiwan Univ, Inst Plant Biol, Taipei 10764, TaiwanChinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China
Yu, Chun-Wei
Chen, Chia-Yang
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机构:
Natl Taiwan Univ, Inst Plant Biol, Taipei 10764, TaiwanChinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China
Chen, Chia-Yang
Tai, Ready
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Natl Taiwan Univ, Inst Plant Biol, Taipei 10764, TaiwanChinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China
Tai, Ready
Wu, Keqiang
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Natl Taiwan Univ, Inst Plant Biol, Taipei 10764, TaiwanChinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China
机构:
Aichi Canc Ctr Res Inst, Div Virol, Chikusa Ku, Nagoya, Aichi 4648681, JapanAichi Canc Ctr Res Inst, Div Virol, Chikusa Ku, Nagoya, Aichi 4648681, Japan
Murata, Takayuki
Hotta, Naoe
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Aichi Canc Ctr Res Inst, Div Virol, Chikusa Ku, Nagoya, Aichi 4648681, JapanAichi Canc Ctr Res Inst, Div Virol, Chikusa Ku, Nagoya, Aichi 4648681, Japan
Hotta, Naoe
Toyama, Shigenori
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Aichi Canc Ctr Res Inst, Div Virol, Chikusa Ku, Nagoya, Aichi 4648681, Japan
Nagoya City Univ, Dept Oncol, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, JapanAichi Canc Ctr Res Inst, Div Virol, Chikusa Ku, Nagoya, Aichi 4648681, Japan
Toyama, Shigenori
Nakayama, Sanae
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机构:
Aichi Canc Ctr Res Inst, Div Virol, Chikusa Ku, Nagoya, Aichi 4648681, JapanAichi Canc Ctr Res Inst, Div Virol, Chikusa Ku, Nagoya, Aichi 4648681, Japan
Nakayama, Sanae
Chiba, Shigeki
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机构:
Aichi Canc Ctr Res Inst, Div Virol, Chikusa Ku, Nagoya, Aichi 4648681, JapanAichi Canc Ctr Res Inst, Div Virol, Chikusa Ku, Nagoya, Aichi 4648681, Japan
Chiba, Shigeki
Isomura, Hiroki
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机构:
Aichi Canc Ctr Res Inst, Div Virol, Chikusa Ku, Nagoya, Aichi 4648681, JapanAichi Canc Ctr Res Inst, Div Virol, Chikusa Ku, Nagoya, Aichi 4648681, Japan
Isomura, Hiroki
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Ohshima, Takayuki
Kanda, Teru
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机构:
Aichi Canc Ctr Res Inst, Div Virol, Chikusa Ku, Nagoya, Aichi 4648681, JapanAichi Canc Ctr Res Inst, Div Virol, Chikusa Ku, Nagoya, Aichi 4648681, Japan
Kanda, Teru
Tsurumi, Tatsuya
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机构:
Aichi Canc Ctr Res Inst, Div Virol, Chikusa Ku, Nagoya, Aichi 4648681, Japan
Nagoya City Univ, Dept Oncol, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, JapanAichi Canc Ctr Res Inst, Div Virol, Chikusa Ku, Nagoya, Aichi 4648681, Japan
机构:
Mt Sinai Sch Med, Brookdale Dept Mol Cell & Dev Biol, New York, NY 10029 USAMt Sinai Sch Med, Brookdale Dept Mol Cell & Dev Biol, New York, NY 10029 USA
Siatecka, Miroslawa
Xue, Li
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机构:
Mt Sinai Sch Med, Brookdale Dept Mol Cell & Dev Biol, New York, NY 10029 USAMt Sinai Sch Med, Brookdale Dept Mol Cell & Dev Biol, New York, NY 10029 USA
Xue, Li
Bieker, James J.
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机构:
Mt Sinai Sch Med, Brookdale Dept Mol Cell & Dev Biol, New York, NY 10029 USAMt Sinai Sch Med, Brookdale Dept Mol Cell & Dev Biol, New York, NY 10029 USA